Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.

GA ČR

GAP207/10/2207
New Nonplanar Polyaromatic Systems of High Complexity: Their Synthesis and Properties
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Stará Irena
Research years: 2010-2014

GAP208/10/1724
Studium struktury a dynamiky povrchu ledu za přítomnosti příměsí a atmosférických polutantů pomocí molekulových simulací
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Roeselová Martina
Research years: 2010-2014

GAP207/11/0344
Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Hocek Michal
Research years: 2011-2015

GAP207/11/0108
Novel types of acyclic nucleoside phosphonates with potential antimalarial activity:hypoxanthine-guanine-xanthine phosphoribosyltransferase inhibitors
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Hocková Dana
Research years: 2011-2014

GAP208/11/0295
In silico drug design based on advanced semiempirical quantum mechanical methods accurately describing noncovalent interactions
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Hobza Pavel
Research years: 2011-2015

GAP208/11/0105
Expanding the Optical Activity Method to the Realm of Biomolecules
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Bouř Petr
Research years: 2011-2015

GAP302/11/1481
Serine proteases of human parasite Schistosoma mansoni and their function in host-parasite interactions
Contractor: Institute of Molecular Genetics of the ASCR, v. v. i.; Biology Centre of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Dvořák Jan; Horn Martin
Research years: 2011-2014

GAP208/11/0436
Vibrational non-harmonicity and quantum effects in molecular dynamics. Constructing pair-potentials using the homotopic shape deformation (morphing
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Špirko Vladimír
Research years: 2011-2014

GAP206/12/0453
Affinity capillary electromigration methods for selective nanoanalysis of biomolecules and investigation of their interactions
Contractor: Institute of Physiology of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Mikšík Ivan; Kašička Václav
Research years: 2012-2014

GAP108/12/0640
Biocompatible nanodiamond probes for in vivo multimodal bioimaging
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; Institute of Macromolecular Chemistry of the ASCR, v. v. i.; Nuclear Physics Institute of the ASCR, v. v. i.
Principal investigator: Cígler Petr; Filippov Sergey; Štursa Jan
Research years: 2012-2014

GBP206/12/G151
Center of novel approaches to bioanalysis and molecular diagnostics
Contractor: Institute of Biophysics of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Fojta Miroslav; Hocek Michal
Research years: 2012-2018

GAP207/12/0846
Transition metal catalyzed reactions of organo-sulfur compounds in cross-coupling reactions. Oxidative mobilization of catalyst
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Šrogl Jiří
Research years: 2012-2014

GPP207/12/P625
Towards cyclohexenyl and cyclohexyl locked nucleic acids
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Šála Michal
Research years: 2012-2014

GAP304/12/0847
Glutamate Carboxypeptidase II and its role in cancer development
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Konvalinka Jan
Research years: 2012-2014

GAP206/12/0750
Lipidome of vernix caseosa: comprehensive analysis and biological variability
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Cvačka Josef
Research years: 2012-2015

GBP208/12/G016
Controlling structure and function of biomolecules at the molecular scale: theory meets experiment
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.
Principal investigator: Hobza Pavel; Hof Martin
Research years: 2012-2018

GAP303/12/0172
Structure-activity relationship (SAR) study of immunosuppressive effects of pyrimidine analogues
Contractor: Institute of Experimental Medicine of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Zídek Zdeněk; Janeba Zlatko
Research years: 2012-2016

GAP303/12/1464
Neurosteroid modulation of NMDA receptors
Contractor: Institute of Physiology of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Vyklický ml. Ladislav; Chodounská Hana
Research years: 2012-2016

GAP208/12/1318
Study of Effects of Intermolecular Interactions on the Character of Electronically Excited States of Nucleic Acids Bases
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Nachtigallová Dana
Research years: 2012-2014

GAP303/12/0576
Effect of different types of antidiabetic interventions on the development of neurodegenerative changes in brain of diabetic mice
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Maletínská Lenka
Research years: 2012-2014

GAP206/12/1093
Development of the New Analytical Methods for Analysis of Extremely Long-Chain Aliphatic Hydrocarbons
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Vrkoslav Vladimír
Research years: 2012-2014

GAP207/12/0072
Development of new methodologies towards (pentafluorosulfanyl)benzenes
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Beier Petr
Research years: 2012-2014

GBP106/12/G015
Intelligent design of nanoporous adsorbents and catalysts
Contractor: J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Čejka Jiří; Bludský Ota
Research years: 2012-2018

GP13-25137P
Biogenesis of (E)-1-nitropentadec-1-ene in soldiers of the termite genus Prorhinotermes
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Jirošová Anna
Research years: 2013-2015

GP13-01214P
Cuby - integrative software framework for computational chemistry
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Řezáč Jan
Research years: 2013-2015

GA13-17224S
Two-dimensional capillary electromigration methods for separation, analysis and characterization of biomolecules
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; Institute of Physiology of the ASCR, v. v. i.
Principal investigator: Kašička Václav; Mikšík Ivan
Research years: 2013-2015

GA13-32974S
Enantioseparations of important analytes: Novel helical dications as chiral selectors
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Koval Dušan
Research years: 2013-2015

GP13-25354P
Evolutionary trends in chemical and mechanical defence in the termite subfamily Termitinae
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Kyjaková Pavlína
Research years: 2013-2015

GP13-21409P
Interactions of metal and nutrient ions with high priority pesticides in soil and on biomembranes
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Jaklová Dytrtová Jana
Research years: 2013-2015

GA13-40188S
Conceptually new catalytic traceless asymmetric oxidative anionic-radical domino reactions
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Jahn Ullrich
Research years: 2013-2015

GA13-03978S
Magnetic circular dichroism as an analytical tool for fullerenes and carbon nanostructures
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Bouř Petr
Research years: 2013-2016

GA13-14105S
Metabonomics of mouse models of obesity and lipoatrophy - studies of metabolic pathways perturbations, disease progression and therapy response
Contractor: Institute of Microbiology of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Kuzma Marek; Železná Blanka
Research years: 2013-2016

GA13-19561S
Design, characterization and mechanism of action of novel inhibitors of HIV assembly
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Konvalinka Jan
Research years: 2013-2015

GA13-26526S
Novel DNA and RNA oligonucleotides with Phosphonothioate and Phosphonoamidate Internucleotide Linkages
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Rosenberg Ivan
Research years: 2013-2016

GA13-27676S
Pyramidalization of the glycosidic nitrogen in nucleic acids; linking the structural phenomenon with chemistry of N-glycosidic bond cleavage
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Sychrovský Vladimír
Research years: 2013-2016

GA13-24880S
Structure and Properties of Modified Components of Nucleic Acids
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Pohl Radek
Research years: 2013-2015

GA13-19213S
Synthesis of helical cyanines, their chirality, self-assembly, and redox switching
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.
Principal investigator: Teplý Filip; Pospíšil Lubomír
Research years: 2013-2015

GA13-11043S
The role of hemoglobin in tick metabolism and transmission of tick-borne pathogens
Contractor: Biology Centre of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Kopáček Petr; Mareš Michael
Research years: 2013-2017

GA13-06181S
Investigation of lipid Langmuir monolayers interacting with atmospheric oxidants and pollutants by molecular simulations
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.
Principal investigator: Roeselová Martina; Cwiklik Lukasz
Research years: 2013-2015

GA14-00431S
3-Nitro-L-tyrosine in structures of neurodegenerative proteins
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Šebestík Jaroslav
Research years: 2014-2016

GP14-18521P
Protein adsorption on molecular sieves: Ab initio modeling
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Rubeš Miroslav
Research years: 2014-2016

GA14-04291S
Hibernation versus aestivation in bumblebees: A lipidomic study.
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Valterová Irena
Research years: 2014-2016

GA14-07101S
Combined Experimental and Theoretical Investigation of Catalytic Properties of Metal Organic Frameworks
Contractor: J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Čejka Jiří; Bludský Ota
Research years: 2014-2016

GA14-17305S
Insulin mimetics
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Jiráček Jiří
Research years: 2014-2016

GA14-04289S
Modifications and bioorthogonal reactions in the major groove of DNA for regulation of protein binding and gene expression
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; Institute of Microbiology of the ASCR, v. v. i.
Principal investigator: Hocek Michal; Krásný Libor
Research years: 2014-2016

GA14-14082S
Molecular dynamics of essential building blocks of biomolecules: experiments in molecular beams and theory.
Contractor: J. Heyrovsky Institute of Physical Chemistry of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Poterya Viktoriya; Nachtigallová Dana
Research years: 2014-2016

GA14-21893S
Nanomechanics of RNA and DNA structural motifs
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Lankaš Filip
Research years: 2014-2016

GA14-03564S
Novel Endohedral Actinide Fullerenes and Their Characterisation. From Spectroscopy to Molecular Devices
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Straka Michal
Research years: 2014-2016

GA14-02337S
New Functionalization of Gold Surfaces
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Michl Josef
Research years: 2014-2016

GA14-31419S
Computational Design of Minimalistic Metallopeptides: ‘En Route’ to Disentangling the Catalytic Power of Metalloproteins
Contractor: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Rulíšek Lubomír
Research years: 2014-2016