... / Bioorganic and Medicinal Chemistry / Marcela Krečmerová / Papers / 2013

2013

Krečmerová M., Jansa P., Dračínský M., Sázelová P., Kašička V., Neyts J., Auwerx J., Kiss E., Goris N., Stepan G., Janeba Z.:

9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evalution in vitro.

Biooorg. Med. Chem. 2013, 21, 1199-1208.

Keough D. T., Špaček P., Hocková D., Tichý T., Vrbková S., Slavětínská L., Janeba Z., Naesens L., Edstein M. D., Chavchich M., Wang T-H., de Jersey J., Guddat L. W.:

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6‑oxopurine phosphoribosyl transferases and have antimalarial activity.

J. Med. Chem. 2013, 56, 2513-2526.

Keough D. T., Hocková D., Rejman D., Špaček P., Vrbková S., Krečmerová M., Eng W. S., Jans H., West N. P., Naesens L. M. J., de Jersey J., Guddat L. W.:

Inhibition of the Escherichia coli 6‑Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents.

J. Med. Chem. 2013, 56, 6967−6984.

Coen N., Duraffour S., Naesens L., Krečmerová M., Van den Oord J., Snoeck R., Andrei G.:

Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells.

J. Virol. 2013, 87, 12422-12432.