Institute of Experimental Botany AS CR
We are Discovering the Plant World

Pleskot R., Li J., Žárský V., Potocký M. and Staiger C. J.
TRENDS IN PLANT SCIENCE in press: , 2013

Keywords:
Abstract: Plants respond to diverse biotic and abiotic stimuli as well as to endogenous developmental cues. Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). PA is a key signaling intermediate in animals, but its targets in plants are relatively uncharacterized. Recent studies have demonstrated that the cytoskeleton is a major target of PLD–PA signaling and identified a positive feedback loop between actin turnover and PLD activity. Moreover, two cytoskeletal proteins, capping protein and MAP65-1, have been identified as PA-binding proteins regulating actin and microtubule organization and dynamics. In this review, we highlight the role of the PLD–PA module as an important hub for housekeeping and stress-induced regulation of membrane-associated cytoskeletal dynamics. IEB authors: Roman Pleskot, Martin Potocký, Viktor Žárský