The purpose of this project, coordinated by the Institute of Molecular Genetics of the ASCR, is to support basic research in chemical biology and genetics and offers Open Access to academic researchers. This infrastructure is equipped with state-of-the-art technology that includes an integrated robotic system for high-throughput screening, a system for automated microscopic high-content analysis and an integrated robotic system for compound storage and management. Its mission is to create a national infrastructure for chemical biology comprised of the national compound collection and the database that enable identification of research tools and probes to be used in basic research and development of potential therapeutics. CZ-OPENSCREEN is a priority project within The National Roadmap of the Large Infrastructures and will serve as a National node in the ESFRI infrastructure EU-OPENSCREEN.