Organic Chemistry

Tutor	Ing. Petr Beier, Ph.D.
Team	Petr Beier
Topic	Enantioselective fluoroalkylations with fluorinated C1 synthons
Faculty	FCHT VŠCHT / PřF UK
Abstract	The project will be focused on the development of new fluorinated C1 synthons and they use in fluoroalkyl group transfer reactions especially organocatalytic enantioselective ones. In particular, new methodologies will be developed for diastereoselective and enantioselective transfer of fluorine-containing groups using novel fluorinated nitromethanes and phoshonates. For representative publications, see: 1. Opekar, Pohl, Beran, Rulisek, Beier: Chem. Eur. J. 2014, in press (DOI: 10.1002/chem.201303817) 2. Opekar, Pohl, Eigner, Beier: J. Org. Chem. 2013, 78, 4573.