Department of Syntheses IIC

The topics in the Department is represented by fundamental research on boron clusters, but its results are traditionally devoted also to search for practical implications of these interesting compounds. Boron chemistry in Řež has been gradually developping since early 1960's, in fact; it  hence forms one of cornerstones of the Institute of Inorganic Chemistry. Over decades of systematic research initiated by group fathers, J. Plešek, S. Heřmánek and B. Štíbr, the Group continues to develop synthetic routes to new boranes, carboranes, hereroboranes and metallacarboranes, along with development of NMR, HPLC and MS methods for compound's separation and characterization. The practical applications iclude in particular entries into fields of radionuclide extraction, medicinal and material chemistry. 

• 11-vertex clusters with three or more cage heteroatoms as analogues of cyclopentadienyl anion (Prize of Academy of Sciences of CR in 2006)
• boranes an carboboranes as low-nucleophilic weakly-coordinating anions
• modified metallacarboranes as robust extracting agents for separation of radionuclides from spent nuclear fuel
• carborane and metallacarborne derivatives with virostatic and cytostatic activity
• chemistry of macropolyhedral boranes
• surface modification of gold and silver surface by carborane and borane thiols

The topics are listed with more details in the section Research

Department has several laboratories completely equipped for synthesis of boron clusters including the work in an inert atmosphere. Newly prepared compounds are characterised using own HPLC with UV-Vis or MS, GC-MS and NMR.

• Plešek J.: Potential Applications of the Boron Cluster Compounds, Chem. Rev., 92(2), 269—278, 1992
• Štíbr B.: Carboranes Other than C₂B₁₀H₁₂, Chem. Rev., 92(2), 225—250, 1992
• King B. T., Janoušek Z., Grüner B., Trammell M., Noll B. C., Michl J.: Dodecamethylcarba-closo-dodecaborate^- anion, CB₁₁Me₁₂^-, J. Am. Chem. Soc., 118(13), 3313—3314, 1996
• Jelínek T., Plešek J., Heřmánek S., Štíbr B.: Chemistry of Compounds with the 1-carba-closo-dodecaborane(12) Framework, Collect. Czech. Chem. Commun., 51(4), 819—829, 1986
• Plešek J., Jelínek T., Drdáková E., Heřmánek S., Štíbr B.: A Convenient Preparation of 1-CB₁₁H₁₂- and its C-amino Derivatives, Collect. Czech. Chem. Commun., 49(7), 1559—1562, 1984
• From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease, Cígler P., Kožíšek M., Řezáčová P., Brynda J., Otwinowski Z., Pokorná J, Plešek J., Grüner B., Dolečková-Marešová L., Máša M., Sedláček J., Bodem J., Krausslich H.G., Král V., Konvalinka J., Proc. Nat. Acad. Sci USA, 102 (43), 15394-15399, 2005