Organization scheme of IPAG CAS, v.v.i.


Laboratory of Tumor Biology


Head of department:
Červinková Monika , RNDr.,MUDr., PhD.
Activity:

We focus on immunological mechanisms involved in cancer progression and in spontaneous regression of tumors. Using animal models we study how tumor-specific immunity and tumor regression is induced naturally or how it can be induced experimentally.

MeLiM strain of minipigs with hereditary melanoma is a unique model in which after a period of tumor progression and metastasis a spontaneous tumor regression occurs leading to complete cure. Tumor regression in MeLiM is associated with infiltration of tumors with cells of the immune system, but their exact role in tumor regression is not known.

Specific aims

  • Characterize dynamic changes in composition of immune cell subpopulations in blood and in tumor tissue in the course of melanoma progression and spontaneous regression
  • Identify melanoma-associated antigens; characterize antigen-specific T and B cell responses in MeLiM and their role in tumor regression
  • Identify possible triggers of spontaneous tumor regression in MeLiM and their link to induction of tumor-specific immune responses
  • Study immune response after tumor treatment by surgical devitalization technique

 

Address:

ÚŽFG AV ČR, v.v.i.

Laboratory of tumour biology

Rumburská 89

277 21 Liběchov

Czech republic

  Head of laboratory:

    Červinková Monika , RNDr.,MUDr., PhD.

  Scientists:

    Horák Vratislav , RNDr., CSc.
    Klaudy Jiří , Ing.,CSc.
    Šinkorová Zuzana , doc.,MVDr.,Ph.D.
    Vannucci Luca , MUDr., PhD.

  Postdocs:

    Kučerová Petra , Mgr.,PhD.
    Palánová Anna (Hrdlicová), Ing., PhD.

  PhDs:

    Čížková Jana , Ing.
    Mishra Rajbardhan , Mgr.

  Lab Technicians:

    Klučinová Jitka
    Šestáková Jaroslava

Organization chart of instiute (click here for zoom)

mapy.cz

LIBĚCHOV
PRAHA
BRNO

  Liběchov
Rumburská 89
277 21 Liběchov
tel.: 315 639 532
fax: 315 639 510
Praha
Vídeňská 1083
142 20 Praha 4-Krč
tel.: 267 090 501
fax: 267 090 500
Brno
Veveří 97
602 00 Brno 2
tel.: 532 290 136
fax: 541 212 988
matousova@iach.cz