Kutil Z., Temml V., Maghradze D., Přibylová M., Dvořáková M., Schuster D., Vaněk T., Landa P.
MEDIATORS OF INFLAMMATION
2014:
1-8,
2014
Klíčová slova:
Abstrakt:
Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63–94%, cyclooxygenase-2 (COX-2) activity in the range of 20–44% (tested at a concentration of 5 mL/L), and 5-lipoxygenase (5-LOX) activity in the range of 72–84% (at a concentration of 18.87 mL/L). White wines inhibited 5-LOX in the range of 41–68% at a concentration of 18.87 mL/L and did not inhibit COX-1 and COX-2. Piceatannol (IC50 = 0.76
Autoři z ÚEB: Marcela Dvořáková,
Přemysl Landa,
Marie Kvasnicová,
Tomáš Vaněk
Čeština
English