Dvořáková M., Nencka R., Dejmek M., Zbornikova E., Březinová A., Přibylová M., Pohl R., Migaud M.E., Vaněk T.
ORGANIC & BIOMOLECULAR CHEMISTRY
11:
5702–5713,
2013
Keywords:
Alkylcarbonate; Mechanical grinding; Ribose derivatives; Sirtuin
Abstract:
The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
IEB authors: Marcela Dvořáková,
Marie Kvasnicová,
Tomáš Vaněk
Čeština
English