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Specific aims:
- Biological activity, pharmacokinetics and distribution of stable lipidized analogs of centraly acting neuropeptides (analogs of PrRP and CART peptide) as potential antiobesity therapeutics
- Effects of antidiabetic and antiobesity interventions on development of insulin resistance and Alzheimer pathology
- Biological activity of stable analogs of ghrelin in potential treatment of obesity or cachexia
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