Přibylová M.,Dvořáková M., Vaněk T.
CHEMICKÉ LISTY
104:
1023-1028,
2010
Klíčová slova:
paklitaxel, cílený transport léčiv
Abstrakt:
Paclitaxel is an important anticancer drug, which is used for treatment of ovarian, breast and lung cancer. The paclitaxel treatment shows two main limitations – poor water solubility of the drug and lack of tumor-specificity. Conjugation of paclitaxel with specific targeting compounds might improve its effectivity and decrease undesirable side effects. This review resumes the research results in the last ten years. Many targeted conjugates of paclitaxel were developed, folic acid, hyaluronic acid, monoclonal antibodies, hormones, fatty acids and glucose being used as tumor-targeting moieties in the conjugates. The
conjugates were tested for cytotoxicity; many of them possess a better anticancer activity than free paclitaxel. The targeted delivery of paclitaxel to cancer cells is a potential promising chemotherapy.
Fulltext: kontaktujte autory z ÚEB
Autoři z ÚEB: Marcela Dvořáková,
Marie Kvasnicová,
Tomáš Vaněk
Čeština
English