Educational and Professional Career:

Present position – Laboratory head – Laboratory of Biochemistry and Molecular Biology of Germ Cells, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, v.v.i.

Postdoctoral researcher – 1992-1995 - The Babraham Institute, Cambridge, UK, nature and timing of the commitment to enter meiosis in XX-XY hybrids produced by nuclear transplantation of male germ cells into oocytes

Postdoctoral researcher – 1991-1992 – Ecole Normale Superieure, Lyon, France, correlation of Cdk1 and MAP kinase activities with chromosome condensation during meiotic division of rabbit oocytes

Ph.d. studies – 1984-1989 – Institute of Animal Physiology and Genetics, Libechov, Czech Republic, study of biochemical changes and cell cycle regulation during maturation of mammalian oocytes

MSc. in Biochemistry – 1980-1984 – Prague institute of Chemical Technology, Prague, Czech Republic

Research Interests:

- Cell cycle regulation – biochemical aspects of mammalian oocyte maturation

- Changes in chromatin structure during oocyte meiotic maturation

- Regulation of translation initiation during oocyte meiotic maturation

Selected Recent Publications:

• Susor, A., Jansova, D., Cerna, R., Danylevska, A., Anger, M., Toralova, T., Malik, R., Supolikova, J., Cook, M.S., Oh, J.S., Kubelka, M. (2014): Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR/4F pathway. Nature Commun., 6:6078.
   
• Komrskova, P., Susor, A., Malik, R., Prochazkova, B., Liskova, L., Supolikova, J., Hladky, S., Kubelka, M. (2014): Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes. Plos One, 9:e101222.
   
• Sebestova, J., Danylevska, A., Novakova, L., Kubelka, M., Anger, M. (2012): Lack of response to unaligned chromosomes in mammalian female gametes.. Cell Cycle, 11:3011-3018.
   
• Hornak, M., Jeseta, M., Musilova, P., Pavlok, A., Kubelka, M., Motlik, J., Rubes, J., Anger, M. (2011): Frequency of aneuploidy related to age in porcine oocytes. Plos One, 6:e18892.
   
• Karabinova, P., Kubelka, M., Susor, A. (2011): Proteasomal degradation of ubiquitinated proteins in mammalian oocyte meiosis and fertilization in mammals. Cell Tissue Res., 346:1-9.
   
• Lišková, L., Šušor, A., Pivoňková, K., Karabínová, P., Kubelka, M. (2010): Detection of condensin I and II in maturing pig oocytes. Reprod.Fert.Dev., 22:644-652.
   
• Šušor, A., Lišková, L., Toralová, T., Pavlok, A., Pivoňková, K., Lopatářová, M., Karabínová, P., Šutovský, P., Kubelka, M. (2009): Role of UCH-L1 in anti-polyspermy defense of mammalian eggs. Biol.Reprod., 82:1151-1161.
   
• Kalous, J., Kubelka, M., Šolc, P., Šušor, A., Motlík, J. (2009): Akt (protein kinase B) is implicated in meiotic maturation of porcine oocytes. Reproduction, 138:645-654.
• Pelech, S., Jelínková, L., Šušor, A., Zhang, H., Shi, X., Pavlok, A., Kubelka, M., Kovářová, H. (2008): Antibody Microarray Analyses of Signal Transduction Protein Expression and Phosphorylation during Porcine Oocyte Maturation. J.Proteome Res., 7:2860-2871.
   
• Šušor, A., Ellederová, Z., Halada, P., Kavan, D., Jelínková, L., Kubelka, M., Kovářová H. (2007): Proteomic Analysis of Porcine Oocytes During in vitro Maturation Reveals Essential Role for the Ubiquitin C- terminal hydrolase-L1. Reproduction, 134:559-568.
   
• Ellederová, Z., Kovářová, H., Melo-Sterza, F., Livingstone, M., Tomek, W., Kubelka, M. (2006): Suppression of Translation During in vitro Maturation of Pig Oocytes Despite Enhanced Formation of Cap-binding Protein Complex eIF4F and 4E-BP1 hyperphosphorylation. Mol.Reprod.Dev., 73:68-76.