2015
Martin M. Kaiser, Dana Hocková, Tzu-Hsuan Wang, Martin Dračínský, Lenka Poštová-Slavětínská, Eliška Procházková, Michael D. Edstein, Marina Chavchich, Dianne T. Keough, Luke W. Guddat,* and Zlatko Janeba*
Synthesis and Evaluation of Twelve Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases and Analysis of Different Prodrugs on Their Antimalarial Activity
ChemMedChem 10, 1707-1723, 2015
DOI: 10.1002/cmdc.201500388
Martin Dracinsky, Lucie Čechová, Paul Hodgkinson, Eliška Procházková and Zlatko Janeba
Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics
Chemical Communications 51, 13986-13989, 2015
DOI: 10.1039/C5CC05199A
Zlatko Janeba*
Development of Small-Molecule Antivirals for Ebola
Medicinal Research Reviews, 2015 (published online)
DOI: 10.1002/med.21355
Dana Hocková*, Zlatko Janeba, Lieve Naesens, Michael D. Edstein, Marina Chavchich, Dianne T. Keough and Luke W. Guddat*
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases
Bioorganic & Medicinal Chemistry 23 (17), 5502-5510, 2015
DOI: 10.1016/j.bmc.2015.07.038
Michal Česnek, Petr Jansa, Markéta Šmídková, Helena Mertlíková-Kaiserová, Martin Dračínský, Tarsis F. Brust, Petr Pávek, František Trejtnar, Val J. Watts and Zlatko Janeba*
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis
ChemMedChem 10 (8): 1351-1364, 2015
DOI: 10.1002/cmdc.201500183
Petr Jansa*, Antonín Holý, Martin Dračínský, Viktor Kolman, Zlatko Janeba, Eva Kmoníčková, Zdeněk Zídek*
Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production
Medicinal Chemistry Research 24(5): 2154-2166, 2015
DOI: 10.1007/s00044-014-1285-5
Wai Soon Eng, Dana Hocková*, Petr Špaček, Zlatko Janeba, Nicholas P. West, Kyra Woods, Lieve Naesens, Dianne Therese Keough, and Luke W. Guddat*
The first crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: Complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates whose prodrugs have antituberculosis activity.
Journal of Medicinal Chemistry 58: 4822-4832, 2015
DOI: 10.1021/acs.jmedchem.5b00611
Dianne T. Keough, Dana Hocková*, Zlatko Janeba, Tzu-Hsuan Wang, Lieve Naesens, Michael D. Edstein, Marina Chavchich, and Luke W. Guddat*
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents
Journal of Medicinal Chemistry 58: 827-846, 2015
DOI: 10.1021/jm501416t
Dana Hocková*, Šářka Rosenbergová, Petra Ménová, Ondra Páv, Radek Pohl, Pavel Novák, Ivan Rosenberg*
N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides
Organic & Biomolecular Chemistry 13: 4449-4458, 2015
DOI: 10.1039/C4OB02265C
