Employees

Projects

Horák Vratislav , RNDr., CSc.


Function:
Profession:
E-mail:
Telephone: +420 315 639 587
Mobile phone:
Department: Laboratory of Tumor Biology
Building: Liběchov/
Institutional service phone: 287
Web:

Curriculum vitae:

1968–1973

university studies - the Faculty of Science, the Charles University, Prague

(biology, specialization - animal genetics)

1974–1978

postgraduate student - the Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, Liběchov

1979

M.Sc. - the Faculty of Science, the Charles University, Prague

1980

Ph.D. - the Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, Liběchov

1980 - 1987

researcher - the Institute of Animal Physiology and Genetics, Czechoslovak Academy of Sciences, Liběchov

1988 - 2003

senior research - the Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Liběchov

2004 – at present

executive resercher - the Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v.v.i., Liběchov

2001 - dosud

Head of the Laboratory of Tumour Biology, the Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v.v.i., Liběchov

Specialization:

Experimental oncology; cancer immunotherapy; malignant melanoma; animal cell in vitro cultivation, characterization and differentiation; developmental biology; stem cells; cytokines

Societies:

Czechoslovak Biological Society

Czech Histo- and Cytochemical Society

European Society for Pigment Cell Research

Internship abroad:

1987, 1988

Institute for the Biology of Farm Animals, Dummerstorf, DDR

1993,1995, 1996,1998

Institut National de la Recherche Agronomique, Jouy-en-Josas, France

1994, 1996

Institute of Plant Genetics, Gatersleben, Germany

Publications:

1983

Horák V.: A successive histochemical staining for succinate dehydrogenase and "reversed"-ATPase in a single section for the skeletal muscle fibre typing. Histochemistry 78: 545-553

1989

Horák V., Hruban V., Dvořák P.: The tissue distribution of Ia- and IgM-positive cells in adult and newborn miniature pigs. Anat.Histol.Embryol. 18: 157-164

1989

Horák V., Matolín S.: Inhibition reactivation myofibrillar ATPase technique for demonstration of three fibre types in a single cryostat muscle section. Stain Technol. 65: 85-89

1995

Horák V.: Fibre type differentiation during postnatal development of miniature pig skeletal muscle. Reprod.Nutr.Dev. 35:725-736

1995

Rohwedel J., Horák V., Hebrok M., Füchtbauer E.-M., Wobus A.M.: M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp.Cell Res. 220: 92-100

1997

Dvořák P., Fléchon J.E., Thompson E., Horák V., Adenot P., Renard J.P.: Embryoglycans regulate FGF-2-mediated mesoderm induction in the rabbit embryo. J.Cell Sci. 110: 1-10

1999

Horák V., Fortýn K., Hruban V., Klaudy J.: Hereditary melanoblastoma in miniature pigs and its successful therapy by devitalization technique. Cell. Mol.Biol.  45: 1119-1129

2003

Boisgard, R., Vincent-Naulleau, S., Leplat, J.-J., Bouet, S., Le Chalony, C., Tricaud, Y., Horák, V., Geffrotin, C., Frelat, G., Tavitian, B.: A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs. Eur. J. Nucl. Med. Mol. Imaging 30: 826-834.

2003

Borovanský, J., Horák, V., Elleder, M., Fortýn, K., Smit, N.P.M., Kolb, A.M.: Biochemical characterization of a new melanoma model – the minipig MeLiM strain. Melanoma Res. 13: 1-6.

2003

Le Chalony C., Renard C., Vincent-Naulleau S., Crechet F., Leplat J.J., Tricaud Y., Horák V., Gruand J., Le Roy P., Frelat G., Geffrotin C.: CDKN2A region polymorphism and genetic susceptibility to melanoma in the MeLiM swine model of familial melanoma. Int. J. Cancer 103: 631-635

2004

Geffrotin, C., Crechet, F., Le Roy, P., Chalony, C., Leplat, J. J., Iannuccelli, N., Barbosa, A., Renard, C., Gruand, J., Milan, D., Horák, V., Tricaud, Y., Bouet, S., Franck, M., Frelat, G., Vincent-Naulleau, S.: Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model. Int. J. Cancer, 110: 39-50

2004

Hruban, V., Horák, V., Fortýn, K., Hradecký, J., Klaudy, J., Smith, D.M., Reisnerová, H., Majzlík, I.: Inheritance of malignant melanoma in the MeliM strain of miniature pigs. Vet. Med - Czech. 49: 453-459

2004

Vincent-Naulleau, S., LeChalony, C., Leplat, J., Bouet, S., Bailly, C., Spatz, A., Vielh, P., Avril, M.F., Tricaud, Y., Gruand, J., Horák, V., Frelat, G., Geffrotin, C.: Clinical and histopathological characterization of cutaneous melanomas in the Melanoblastoma-bearing Libechov Minipig model. Pigment Cell Res. 17: 24-35.

2005

Horák V., Morávková A, Málek O, Hradecký J, Klaudy J, Strnádel J, Míšek I: Lokální chirurgická ischemizace – devitalizace nádorové tkáně. In: Angiogenéza a lymfangiogenéza (eds. Lešník F., Jenča A., Danko J. et al.), Univerzita veterinárskeho lekárstva a Lekárská fakulta UPJŠ, Košice (ISBN 80-8077-023-9), str. 41-51

2005

Moravkova A., Malek O., Pokorna E., Strnadel J., Hradecky J., Horak V.: Immune characterization of the Lewis rats inoculated with K2 sarcoma cells and newly derived R5-28 malignant cells. Folia Biol. (Praha) 51: 159-165

2005

Svoboda M., Eichlerová K., Horák V., Hradecký J.: Development of haematological incidences in Melanoma-bearing Libechov minipigs. Acta Vet. (Brno) 74: 603-612

2007

Du Z.Q., Vincent-Naulleau S., Gilbert H., Vignoles F., Crechet F., Shimogiri T., Yasue H., Leplat J-J., Bouet S., Gruand J., Horak V., Milan D., Le Roy P., Geffrotin C.: Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. Int. J. Cancer 120: 303-320

2007

Strnádel J., Kverka M., Horák V., Vannucci L., Usvald D., Hlučilová J., Plánská D., Váňa P., Reisnerová H., Jílek F.: Multiplex analysis of cytokines involved in tumour growth and spontaneous regression in a rat sarcoma model. Folia Biol. (Praha) 53: 216-219

2008

Rambow F., Malek O., Geffrotin C., Leplat J.-J., Bouet S., Piton G., Hugot K., Bevilacqua C., Horák V., Vincent-Naulleau S.: Identification of differentially expressed genes in spontaneously regressing melanoma using the MeLiM swine model. Pigment Cell Melanoma Res. 21: (doi: 10.1111/j.1755-148X.2008.00442.x)

2008

Rovenská M., Hlouchová K., Šácha P., Mlčochová P., Horák V., Zámečník J., Bařinka C., Konvalinka J.: Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs. Prostate 68: 171-182

2009

Krizkova S., Fabrik I., Adam V., Kukacka J., Prusa R., Trnkova L., Strnadel J., Horak V., Kizek R.: Effect of reduced glutathione, surface active agents, and ionic strength on the detection of metallothioneins by using of Brdicka reaction. Electroanalysis 21: 640-644

2011

Putnová I., Odehnalová S., Horák V., Stehlík L., Míšek I., Lozanoff S., Buchtová M.: Comparative morphology of normal and cleft minipigs demonstrates dual origin of incisors. Arch. Oral Biol. 56: 1624-1634

 

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