Institute of Experimental Botany AS CR
We are Discovering the Plant World

New Analogues of the Potent Cytotoxic Saponin OSW-1

Wojtkielewicz, A.; Dlugosz, M.; Maj, J.; Morzycki, J.W.; Nowakowski, M.; Renkiewicz, J.; Strnad, Miroslav; Swaczynová, Jana; Wilczewska, A.Z.; Wojcik, J.
JOURNAL OF MEDICINAL CHEMISTRY 50 [15] : 3667-3673 , 2007
Keywords: NATURAL PRODUCT OSW-1; ANTITUMOR SAPONIN; ORNITHOGALUM-SAUNDERSIAE

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

Kryštof, Vladimír; Cankař, Petr; Fryšová, I.; Slouka, J.; Kontopidis, G.; Džubák, P.; Hajdúch, M.; Srovnal, J.; de Azevedo Jr., W.F.; Orság, Martin; Paprskářová, Martina; Rolčík, Jakub; Látr, Aleš; Fischer, P.M.; Strnad, Miroslav
JOURNAL OF MEDICINAL CHEMISTRY 49 [22] : 6500-6509 , 2006
Keywords: DEPENDENT KINASE INHIBITORS; POLYMERASE-II TRANSCRIPTION; TUMOR-NECROSIS-FACTOR

Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters

Soural, M.; Hlaváč, J.; Hradil, P.; Fryšová, I.; Hajdúch, M.; Bertolasi, V.; Maloň, Michal
JOURNAL OF MEDICINAL CHEMISTRY 41 [4] : 467-474 , 2006
Keywords: Quinolinone; Cytotoxic activity; X-ray structure