Čeština
EnglishEvaluation of anti-inflammatory activity of selected legumes from Pakistan: In vitro inhibition of Cyclooxygenase-2
Zia-Ul-Haq M., Landa P., Kutil Z., Qayum M., Ahmad S.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 26: 185-187, 2013
Keywords: Anti-inflammatory, legumes, COX-2, lentil, soybean, black gram, green gram
Abstract: Crude methanolic extracts of selected legumes namely, black gram (Vigna mungo L.), green gram (Vigna radiata (L.) R. Wilczek ), soybean (Glycine max (L.) Merr.) and lentil (Lens culinaris Medik.) were investigated for antiinflammatory effects, using COX-2 producing PGE2 inhibitory assay. Percentage inhibition observed was 73.93, 79.84, 92.17 and 74.47 for black gram, green gram, soybean and lentil respectively at 20μg/ml extract concentration. The 100μg/ml concentration showed increase in the percent inhibition except for soybean. This is the first report on COX-2 inhibitory potential of food legumes.
IEB authors: Přemysl Landa
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 26: 185-187, 2013
Keywords: Anti-inflammatory, legumes, COX-2, lentil, soybean, black gram, green gram
Abstract: Crude methanolic extracts of selected legumes namely, black gram (Vigna mungo L.), green gram (Vigna radiata (L.) R. Wilczek ), soybean (Glycine max (L.) Merr.) and lentil (Lens culinaris Medik.) were investigated for antiinflammatory effects, using COX-2 producing PGE2 inhibitory assay. Percentage inhibition observed was 73.93, 79.84, 92.17 and 74.47 for black gram, green gram, soybean and lentil respectively at 20μg/ml extract concentration. The 100μg/ml concentration showed increase in the percent inhibition except for soybean. This is the first report on COX-2 inhibitory potential of food legumes.