Laboratory of Biochemistry of Membrane Receptors
A) HEK 293 cells expressing VSV-TRH-R-GFP fusion protein B) A simplified model of membrane organization of trimeric G proteins, receptors and adenylyl cyclase in plasma membrane
Our research focuses on the cellular and molecular mechanisms of desensitization of hormone response mediated by the activation of G protein coupled receptors (GPCR). G protein coupled receptors are plasma membrane integral proteins which serve as transducers of extracellular signals across the plasma membrane bilayer to the cell interior. GPCR play a key role in the regulation of many physiological processes and functions. Moreover, GPCRs represent one of the most important groups of targets for therapeutics.
Tel.: +420 241 062 478 +420 241 062 533 E-mail: svobodap@fgu.cas.cz
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Department of Biomathematics Laboratory of Biochemistry of Membrane Receptors Vídeňská 1083 142 20 Prague 4
Department of Biomathematics Laboratory of Biochemistry of Membrane Receptors Vídeňská 1083 142 20 Prague 4
The main areas of the research are:
- Opioid receptors and drug addiction
- Cell membrane and membrane domains
- GABA-B receptors
- Biochemistry of free radicals
- Projects
- Publications
- Education and popularization
- Photogallery
The role of cell membrane and function of membrane domains in the regulation of functional activity of trimeric G proteins
Cell (plasma) membrane (PM) serve as a protective barrier, but also plays a role in the cellular communication. The integrity of hydrophobic lipid environment of PM is an important factor affecting… MoreStudies of GABA-B receptors-initiated signaling cascade
Metabotropic receptors for γ-aminobutyric acid (GABA-B receptors) play a crucial role in the regulation of synaptic transmission in CNS. We study the ability of GABA-B receptors to activate… MoreBiochemistry of free radicals
Free radicals are involved in most of the pathologies and also occur under physiological conditions as signal molecules or during remodeling of the tissues. The sites of their production can be… MorePublications 2011 - 2014
2014 Vošahlíková, Miroslava - Jurkiewicz, Piotr - Roubalová, Lenka - Hof, Martin - Svoboda, Petr . High- and low-affinity sites for sodium in delta-OR-G(i)1 alpha (Cys(351)-Ile(351)) fusion protein… MorePublication 2007 - 2010
2010 Bouřová, Lenka - Vošahlíková, Miroslava - Kagan, D. - Dlouhá, Kateřina - Novotný, J. - Svoboda, Petr . Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and… MoreSupport
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