Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:
- high cardiac tolerance to injury early ontogeny,
- increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
- permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
- and altered cardiac tolerance associated with various pathological states.
Projects
The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance.
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Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance.
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Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury.
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Publications
Ravingerová, T. - Ledvényiová-Farkašová, V. - Ferko, M. - Barteková, M. - Bernátová, I. - Pecháňová, O. - Adameová, A. - Kolář, František - Lazou, A.
Pleiotropic preconditioning-like cardioprotective effects of hypolipidemic drugs in acute ischemia–reperfusion in normal and hypertensive rats
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Canadian Journal of Physiology and Pharmacology. 2015, Vol. 93, 7, p. 495-503
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IF = 1.770
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Mathur, P. - Ošťádal, Bohuslav - Romeo, F. - Mehta, J. L.
Gender-Related Differences in Atherosclerosis
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Cardiovascular Drugs and Therapy. 2015, Vol. 29, 4, p. 319-327
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IF = 3.189
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Maslov, L. N. - Naryzhnaya, N. V. - Prokudina, E. S. - Kolář, František - Gorbunov, A. S. - Zhang, Y. - Wang, H. - Tsibulnikov, S.Yu. - Portnichenko, A. G. - Lasukova, T. V. - Lishmanov, Yu. B.
Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors
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Clinical and Experimental Pharmacology and Physiology. 2015, Vol. 42, 5, p. 496-501
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IF = 2.372
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Kochová, P. - Cimrman, R. - Štengl, M. - Ošťádal, Bohuslav - Tonar, Z.
A mathematical model of the carp heart ventricle during the cardiac cycle
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Journal of Theoretical Biology. 2015, Vol. 373, May 21, p. 12-25
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IF = 2.116
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doi
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Chytilová, Anna - Borchert, Gudrun H. - Mandíková-Alánová, Petra - Hlaváčková, Markéta - Kopkan, L. - Khan, M. A. H. - Imig, J. D. - Kolář, František - Neckář, Jan
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Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
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Acta Physiologica. 2015, Vol. 241, 1, p. 97-108
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IF = 4.382
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Horn, P. - Ošťádal, P. - Ošťádal, Bohuslav
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Rowing increases stroke volume and cardiac output to a greater extent than cycling
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Physiological Research. 2015, Vol. 64, 2, p. 203-207
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IF = 1.293
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Holzerová, K. - Hlaváčková, Markéta - Žurmanová, J. - Borchert, Gudrun H. - Neckář, Jan - Kolář, František - Novák, F. - Nováková, O.
Involvement of PKC epsilon in cardioprotection induced by adaptation to chronic continuous hypoxia
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Physiological Research. 2015, Vol. 64, 2, p. 191-201
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IF = 1.293
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Alánová, Petra - Husková, Z. - Kopkan, L. - Sporková, A. - Jíchová, Š. - Neckář, Jan - Imig, J. D. - Klevstig, Martina - Kolář, František - Reddy, N. R. - Falck, J. R. - Sadowski, J. - Nishiyama, A. - Kramer, H. J. - Melenovský, V. - Červenková, L. - Kujal, P. - Vernerová, Z. - Červenka, L.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats
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Vascular Pharmacology. 2015, Vol. 73, -, p. 45-56
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IF = 3.635
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Wasková-Arnoštová, P. - Kašparová, D. - Elsnicová, B. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium
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Cellular Physiology and Biochemistry 2014, roč. 33, 2, p. 310-320. ISSN 1015-8987.
IF = 2.875
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Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Sedmera, David
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Developmental determinants of cardiac sensitivity to hypoxia
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Canadian Journal of Physiology and Pharmacology 2014, roč. 92, 7, p. 566-574. ISSN 0008-4212.
IF = 1.77
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