Laboratory of Growth Substances
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and Institute of Experimental Botany, Academy of Sciences of the Czech Republic (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
Workers
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
scientist
- Jiří Grúz
- Mgr. Ondřej Novák Ph.D.
- Mgr. Lucie Plíhalová Ph.D.
- Mgr. Danuše Tarkowská Ph.D.
- PharmDr. Lubor Urbánek Ph.D.
scientific assistant
- Mgr. Lukáš Spíchal Ph.D.
graduated technical assistant
- Mgr. Ota Blahoušek
- Ivan Petřík
assistant
- Jitka Hansgutová DiS.
technician
- Mgr. Marie Karlická
Research projects
Publications
2016
- NATURE PLANTS 2 Article number: 16013 2016 (External fulltext)
2015
- PLANT GROWTH REGULATION 75 483-492 2015 (External fulltext)
- JOURNAL OF EXPERIMENTAL BOTANY 66 6927–6943 2015 (External fulltext)
- MOLECULAR CELL 57 984-994 2015
- PLANT BIOLOGY 1112 291-296 2015
- PLANT CELL 27 1955-1967 2015
- PHYSIOLOGIA PLANTARUM 154 66-81 2015 (External fulltext)
- STEROIDS 97 107-112 2015 (External fulltext)
-
PHABULOSA controls the quiescent center-independent root meristem activities in Arabidopsis thalianaPLoS GENETICS DOI:10.1371/journal.pgen.100497 2015 (External fulltext)
2014
- PLANTA 240 55-76 2014 (External fulltext)