Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:
- Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
- Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
- Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
- Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).
Projects
Achievements
Publications
Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
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ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood
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Physiological Research. 2015, Vol. 64, 3, p. 303-312
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IF = 1.293
[ASEP]
Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Vernerová, Z. - Zicha, Josef
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Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet
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Journal of Hypertension. 2015, Vol. 33, 1, p. 161-169
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IF = 4.720
[ASEP]
[
doi
]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
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Pathogenetic Mechanisms of Neurogenic Pulmonary Edema
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Journal of Neurotrauma. 2015, Vol. 32, 15, p. 1135-1145
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IF = 3.714
[ASEP]
[
doi
]
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Josef - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
.
Stem cells regenerative properties on new rat spinal fusion model
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Physiological Research. 2015, Vol. 64, 1, p. 119-128
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IF = 1.293
[ASEP]
Ergang, Peter - Vodička, Martin - Soták, Matúš - Klusoňová, Petra - Behuliak, Michal - Řeháková, Lenka - Zach, P. - Pácha, Jiří
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Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats
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Psychoneuroendocrinology. 2015, Vol. 53, Mar 2015, p. 49-59
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IF = 4.944
[ASEP]
[
doi
]
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Recording of blood pressure.
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
