The use of time-of-flight (TOF) information in positron emission tomography (PET) significantly improves the effective sensitivity, enabling better image quality and reduction of scan times, dose and costs. PET manufacturers have recently released systems with 325-400 ps FWHM coincidence resolving time (CRT). Moreover, CRT’s well below 100 ps FWHM have been achieved using short (< 5 mm) scintillation crystals coupled to silicon photomultipliers (SiPMs).
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