Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.
We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:
- Study of influence epigenetic factors on heart development.
- Analysis of mechanisms of embryonic heart failure.
- Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
- Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.
These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.
Projects
Achievements
Publications
Sedmera, David - Kočková, Radka - Vostárek, František - Raddatz, E.
Arrhythmias in the developing heart
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Acta Physiologica. 2015, Vol. 213, 2, p. 303-320
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IF = 4.382
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doi
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Petrovová, E. - Purzyc, H. - Mazenský, D. - Luptáková, L. - Torma, N. - Sopoliga, I. - Sedmera, David
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Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver
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Environmental Toxicology. 2015, Vol. 30, 2, p. 212-222
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IF = 3.197
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doi
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Vostárek, František - Šaňková, Barbora - Sedmera, David
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Studying dynamic events in the developing myocardium
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Progress in Biophysics & Molecular Biology. 2014, roč. 115, 2-3, p. 261-269. ISSN 0079-6107.
IF = 2.274
[ASEP]
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doi
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Tenin, G. - Clowes, Ch. - Wolton, K. - Krejčí, Eliška - Wright, J. A. - Lovell, S. C. - Sedmera, David - Hentges, K. E.
Erbb2 Is Required for Cardiac Atrial Electrical Activity during Development
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PLoS ONE. 2014, roč. 9, 9, e107041. ISSN 1932-6203.
IF = 3.234
[ASEP]
[
doi
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Sochman, J. - Peregrin, J.H. - Pavcnik, D. - Uchida, B.T. - Timmermans, H.A. - Sedmera, David - Benada, Oldřich - Kofroňová, Olga - Keller, F.S. - Rosch, J.
Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study
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Physiological Research 2014, roč. 63, 2, p. 157-165. ISSN 0862-8408.
IF = 1.293
[ASEP]
Sedmera, David - Gourdie, R. G.
Why do we have Purkinje fibers deep in our heart?
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Physiological Research 2014, roč. 63, suppl.1, s9-s18. ISSN 0862-8408.
IF = 1.293
[ASEP]
Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Sedmera, David
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Developmental determinants of cardiac sensitivity to hypoxia
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Canadian Journal of Physiology and Pharmacology 2014, roč. 92, 7, p. 566-574. ISSN 0008-4212.
IF = 1.77
[ASEP]
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doi
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Hejnová, L. - Hahnová, K. - Kočková, Radka - Svatůňková, Jarmila - Sedmera, David - Novotný, J.
Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs
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BioMed Research International. 2014, roč. 2014, 2014, p. 463123. ISSN 2314-6133.
IF = 1.579
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doi
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Haque, A. - Šaňková, Barbora - Kvasilová, A. - Krejčí, Eliška - Sedmera, David
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Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos?
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Folia Biologica. 2014, roč. 60, 5, p. 243-251. ISSN 0015-5500.
IF = 1
[ASEP]
Beneš Jr., Jiří - Ammirabile, G. - Šaňková, Barbora - Campione, M. - Krejčí, Eliška - Kvasilová, A. - Sedmera, David
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The role of connexin40 in developing atrial conduction
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FEBS Letters 2014, roč. 588, 8, p. 1465-1469. ISSN 0014-5793.
IF = 3.169
[ASEP]
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doi
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Kočková, Radka - Svatůňková, Jarmila - Novotný, J. - Hejnová, L. - Ošťádal, Bohuslav - Sedmera, David
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Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo
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American Journal of Physiology-Heart and Circulatory Physiology, 2013, Vol. 304, 6, H895-H902
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IF = 3.629
[ASEP]
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doi
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De la Rosa, A. J. - Domínguez, J. N. - Sedmera, D. - Šaňková, Barbora - Hove-Madsen, L. - Franco, D. - Aránega, A. E.
Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis
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Cardiovascular Research, 2013, Vol. 98, 3, p. 504-514
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IF = 5.940
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doi
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Buffinton, Ch. M. - Fass, D. - Sedmera, David
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Stress and strain adaptation in load-dependent remodeling of the embryonic left ventrikle
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Biomechanics and Modeling in Mechanobiology, 2013, Vol. 12, 5, p. 1037-1051
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IF = 3.331
[ASEP]
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doi
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Bohuslavová, Romana - Škvorová, Lada - Sedmera, David - Semenza, G.L. - Pavlínková, Gabriela
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Increased susceptibility of HIF-1 alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes
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Journal of Molecular and Cellular Cardiology, 2013, Vol. 60, -, p. 129-141
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IF = 5.148
[ASEP]
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doi
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Šaňková, Barbora - Beneš jr, Jiří - Krejčí, Eliška - Dupays, L. - Theveniau-Riussy, M. - Miquerol, L. - Sedmera, David
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The effect of connexin40 deficiency on ventricular conduction system function during development
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Cardiovascular Research, 2012, Vol. 95, 4, p. 469-479
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IF = 5.940
[ASEP]
[
doi
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Krejčí, Eliška - Peševski, Živorad - Dealmeida, A.C. - Mrug, M. - Fresco, V.M. - Argraves, W.S. - Barth, J.L. - Cui, X. - Sedmera, David
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Microarray analysis of normal and abnormal chick ventricular myocardial development
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Physiological Research, 2012, Vol. 61, Suppl.1, S137-S144
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IF = 1.531
[ASEP]
Ammirabile, G. - Tessari, A. - Pignataro, V. - Szumska, D. - Sardo, F.S. - Beneš jr, Jiří - Balistreri, M. - Bhattacharya, S. - Sedmera, David - Campione, M.
Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium
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Cardiovascular Research, 2012, Vol. 93, 2, p. 291-301
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IF = 5.940
[ASEP]
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doi
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Petrovová, E. - Sedmera, David - Luptáková, L. - Mazenský, D. - Danko, J.
Chick development and high dose of bendiocarb
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Journal of Environmental Science and Health Part A-Toxic/Hazardous Substances & Environmental Engineering, 2012, Vol. 47, 9, p. 1312-1318
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IF = 1.252
[ASEP]
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doi
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Sedmera, David - Thompson, R. P.
Myocyte proliferation in the developing heart
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Developmental Dynamics, 2011, Vol. 240, 6, p. 1322-1334
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IF = 2.536
[ASEP]
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doi
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Sedmera, David
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Function and form in the developing cardiovascular system
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Cardiovascular Research, 2011, Vol. 91, 2, p. 252-259
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IF = 6.064
[ASEP]
[
doi
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Petrák, J. - Pospíšilová, J. - Šedinová, M. - Jedelský, P. - Lorková, L. - Vít, O. - Kolář, Michal - Strnad, Hynek - Beneš, J. - Sedmera, David - Červenka, L. - Melenovsky, V.
Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aortocaval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2
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Proteome Science, 2011, Vol. 9, 1, e69
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IF = 2.328
[ASEP]
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doi
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Melenovsky, V. - Beneš, J. - Škaroupková, P. - Sedmera, David - Strnad, Hynek - Kolář, Michal - Vlček, Čestmír - Petrák, J. - Beneš ml., J. - Papoušek, František - Oliyarnyk, O. - Kazdová, L. - Červenka, L.
Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats
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Molecular and Cellular Biochemistry, 2011, Vol. 354, 1-2, p. 83-96
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IF = 2.057
[ASEP]
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doi
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Beneš ml., Jiří - Melenovsky, V. - Škaroupková, P. - Pospíšilová, J. - Petrák, J. - Červenka, L. - Sedmera, David
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Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload
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Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 2011, Vol. 294, 1, p. 102-111
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IF = 1.473
[ASEP]
[
doi
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Beneš, J. - Kazdová, L. - Drahota, Zdeněk - Houštěk, Josef - Medříková, Daša - Kopecký, Jan - Kovářová, Nikola - Vrbacký, Marek - Sedmera, David - Strnad, Hynek - Kolář, Michal - Petrák, J. - Benada, Oldřich - Škaroupková, P. - Červenka, L. - Melenovsky,
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Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats
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Clinical science, 2011, Vol. 121, 1, p. 29-41
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IF = 4.317
[ASEP]
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doi
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Sedmera, David
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Pathways to embryonic heart failure
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American Journal of Physiology-Heart and Circulatory Physiology, 2009, Vol. 297, 5, H1578-H1579
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IF = 3.712
[ASEP]
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doi
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Liška, F. - Šnajdr, P. - Šedová, L. - Šeda, O. - Chylíková, B. - Slámová, P. - Krejčí, E. - Sedmera, David - Grim, M. - Křenová, D. - Křen, Vladimír
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Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat
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Developmental Dynamics, 2009, Vol. 238, 3, p. 673-684
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IF = 2.833
[ASEP]
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doi
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Damon, B. J. - Rémond, M.C. - Bigelow, M.R. - Trusk, T. C. - Xie, W. - Perucchio, R. - Sedmera, David - Denslow, S. - Thompson, R. P.
Patterns of muscular strain in the embryonic heart wall
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Developmental Dynamics, 2009, Vol. 238, 6, p. 1535-1546
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IF = 2.833
[ASEP]
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doi
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Find 5 differences.
Eliška Krejčí with her poster.
