2010
Mertlíková-Kaiserová H., Votruba I., Matoušová M., Holý A., Hájek M.:
Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells.
Anticancer Research 30: 2791-2798 (2010).
Hájek M., Cvilink V., Votruba I., Holý A., Mertlíková-Kaiserová H.:
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
European Journal of Pharmacology 643: 6–12 (2010).
Spáčilová P., Nauš P., Pohl R., Votruba I., Snášel J., Zábranská H., Pichová I., Ameral R., Birkus G., Cihlár T., Hocek M.:
CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases.
ChemMedChem 5: 1386-96 (2010).
Herman B.D., Votruba I., Holý A., Sluis-Cremer N., Balzarini J.:
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.
Journal of Biological Chemistry 285: 12101-12118 (2010).
Šenel P., Tichotová L., Votruba I., Buchta V., Špulák M., Kuneš J., Nobilis M., Krenk O., Pour M.:
Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives.
Bioorganic & Medicinal Chemistry 18: 1988-2000 (2010).
Kočalka P., Rejman D., Vaněk V., Rinnová M., Tomečková I., Králíková S., Petrová M., Páv O., Pohl R., Buděšínský M., Liboska R., Točík Z., Panova N., Votruba I., Rosenberg I.:
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.
Bioorganic & Medicinal Chemistry Letters 20: 862-865 (2010).
Nauš P., Pohl R., Votruba I., Džubák P., Hajdúch M., Ameral R., Birkus G., Wang T., Ray A.S., Mackman R., Cihlar T., Hocek M.:
6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents.
Journal of Medicinal Chemistry 53: 460-470 (2010).
Schiller R., Tichotová L., Pavlík J., Buchta V., Melichar B., Votruba I., Kuneš J., Špulák M. and Pour M.:
3,5-Disubstituted Pyranone Analogues of Highly Antifungally Active Furanones: Conversion of Biological Effect from Antifungal to Cytostatic.
Bioorganic & Medicinal Chemistry Letters 20: 7358-7360 (2010).
Špak J., Holý A., Pavingerová D., Votruba I., Špaková V., Petrzik K.:
New in vitro method for evaluating antiviral activity of acyclic nucleoside phosphonates against plant viruses.
Antiviral Research 88: 296-303 (2010).
Votruba I., Trýznová J., Břehová P., Tloušťová E., Horská K., Fanfrlík J., Přenosil O., Holý A.:
Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners.
Collection of Czechoslovak Chemical Communication 75: 1249-1257 (2010).
Opekar S., Turek P., Pohl R., Klepetářová B., Votruba I., Hocek M., Kotora M.:
[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes.
Heterocycles 82: 895-907 (2010).