StrukturaVědecko-servisní skupinyMedicinální chemie

Medicinální chemie

The mission of the service part of the group consists of:

  • Solid phase synthesis of peptides up to 50 amino acid residues
  • Synthesis of peptide derivatives containing e.g. fluorescent labels, hydrophobic modifications, PEG linkers, special amino acids, dendritic branching, multiple disulfide bridges etc.
  • Synthesis of small molecules, mainly enzyme inhibitors with various warheads
  • Qualitative and quantitative amino acid analysis of peptides and proteins
  • Protein and peptide sequencing using Edman’s method in the standard scale and micro scale
  • Maintenance and standard service of LC-MS-TOF instrument and custom analysis of samples
  • Quantitative amino acid analysis by fluorescent derivatization and HPLC
atom