2015
Vorlová B., Nachtigallová D., Jirásková-Vaníčková J., Ajani H, Jansa P., Řezáč J., Fanfrlík J., Otyepka M., Hobza P., Konvalinka J., Lepšík M.:
Malonate-based inhibitors of mammalian serine racemase: Kinetic characterization and structure-based computational study.
European Journal of Medicinal Chemistry 89, 189-197, 2015.
Kaiser M.M., Hocková D., Wang T.-H., Dračínský M., Poštová-Slavětínská L., Procházková P., Edstein M.D., Chavchich M., Keough D.T., Guddat L.W., Janeba Z.:
Synthesis and Evaluation of Twelve Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases and Analysis of
Different Prodrugs on Their Antimalarial Activity.
ChemMedChem 10: 1707-1723, 2015.
Dračínský M., Čechová L., Hodgkinson P., Procházková E., Janeba Z.:
Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics.
Chemical Communications 51: 13986-13989, 2015.
Janeba Z.:
Development of Small-Molecule Antivirals for Ebola.
Medicinal Research Reviews 35: 1175–1194, 2015.
Hocková D., Janeba Z., Naesens L., Edstein M.D., Chavchich M., Keough D.T., Guddat L.W.:
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases
Bioorganic & Medicinal Chemistry 23: 5502-5510, 2015.
Česnek M., Jansa P., Šmídková M., Mertlíková-Kaiserová H., Dračínský M., Brust T.F., Pávek P., Trejtnar F., Watts V.J., Janeba Z.:
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
ChemMedChem 10: 1351-1364, 2015.
Jansa P., Holý A., Dračínský M., Kolman V., Janeba Z., Kmoníčková E., Zídek Z.:
Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production.
Medicinal Chemistry Research 24: 2154-2166, 2015.
Eng W.S., Hocková D., Špaček P., Janeba Z., West N.P., Woods K., Naesens L., Keough D.T., Guddat L.W.:
The first crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: Complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates
whose prodrugs have antituberculosis activity.
Journal of Medicinal Chemistry 58: 4822-4832, 2015.
Keough D.T., Hocková D., Janeba Z., Wang T.-H., Naesens L., Edstein M.D., Chavchich M., Guddat L.W.:
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax
6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
Journal of Medicinal Chemistry 58: 827-846, 2015.
Hocková D., Rosenbergová Š., Ménová P., Páv O., Pohl R., Novák P., Rosenberg I.:
N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.
Organic & Biomolecular Chemistry 13: 4449-4458, 2015.
