Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.
We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:
- Study of influence epigenetic factors on heart development.
- Analysis of mechanisms of embryonic heart failure.
- Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
- Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.
These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.
Projects
Achievements
Publications
Sedmera, David - Kočková, Radka - Vostárek, František - Raddatz, E.
Arrhythmias in the developing heart
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Acta Physiologica. 2015, Vol. 213, 2, p. 303-320
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IF = 4.382
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Petrovová, E. - Purzyc, H. - Mazenský, D. - Luptáková, L. - Torma, N. - Sopoliga, I. - Sedmera, David
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Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver
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Environmental Toxicology. 2015, Vol. 30, 2, p. 212-222
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IF = 3.197
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doi
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Vostárek, František - Šaňková, Barbora - Sedmera, David
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Studying dynamic events in the developing myocardium
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Progress in Biophysics & Molecular Biology. 2014, roč. 115, 2-3, p. 261-269. ISSN 0079-6107.
IF = 2.274
[ASEP]
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doi
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Tenin, G. - Clowes, Ch. - Wolton, K. - Krejčí, Eliška - Wright, J. A. - Lovell, S. C. - Sedmera, David - Hentges, K. E.
Erbb2 Is Required for Cardiac Atrial Electrical Activity during Development
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PLoS ONE. 2014, roč. 9, 9, e107041. ISSN 1932-6203.
IF = 3.234
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doi
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Sochman, J. - Peregrin, J.H. - Pavcnik, D. - Uchida, B.T. - Timmermans, H.A. - Sedmera, David - Benada, Oldřich - Kofroňová, Olga - Keller, F.S. - Rosch, J.
Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study
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Physiological Research 2014, roč. 63, 2, p. 157-165. ISSN 0862-8408.
IF = 1.293
[ASEP]
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Eliška Krejčí with her poster.
