The research at our departments focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.

Our primary research topics are:

• Consequences of brain injury during early stages of the brain development
• Mechanisms responsible for seizure initiation and termination.
• Impact of seizures on the developing brain
• Development of new diagnostic techniques of epilepsy
• Cognitive and behavioural consequences of epilepsy
• The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
• Impact of antiepileptic therapy of the brain development
• Age-specific mechanisms of seizure initiation and propagation