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Protein Structures

Protein Structures

http://www.biomed.cas.cz/d312/index.php?section=home

Our group is focused on structural biology (the relationship between the structure and function of certain groups of proteins), particularly we focus on the proteins which participate in the signal transmission in the cell. Among methods we use are recombinant protein expression, biophysical characterization, study of intermolecular interactions, protein structure and interaction surfaces. All these methods enable us to better understand the details how the activity and function of protein-protein complexes is regulated. Our research is focused mainly on:

 

  • Structural biology of 14-3-3 proteins and their complexes
  • Study of DNA-binding domain of transcription factor FOXO4
  • Mechanism of regulation of Ask kinases
  • Interaction  of cytoplasmatic domains of TRP channels

Projects

Calmodulin and S100A1 protein interact with N-terminus of TRPM3 channel

Transient receptor potential (TRP) channels are a wide family of non-selective ion channels responsible for monovalent and divalent cation influx into the cells. Members of this family are involved in many sensory processes. We identified several positively charged residues as having a crucial impact on CaM/S100A1 binding.  More

Achievements

Publications

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Contacts

Institute of Physiology AS CR, v.v.i.
Department of Protein Structures

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 191
fax. +420 241 062 477
 

veronika.obsilova@fgu.cas.cz

People

RNDr. Veronika Obšilová, Ph.D.
head of the department

Prof. RNDr. Tomáš Obšil, Ph.D.
senior researcher

RNDr. Miroslava Alblová (born Kopecká), Ph.D.
junior researcher
Ing. Jan Teisinger, CSc.
senior researcher
Ing. Michaela Jirků
PhD student
Mgr. Kristýna Boušová
PhD student
Mgr. Salome Kylarová
PhD student
Mgr. Miroslava Kacířová
PhD student
Mgr. Dana Kalábová (born Žáková) 
PhD student

Mgr. Olívia Petrvalská
PhD student

Mgr. Katarína Pšenáková
PhD student
Bc. Aneta Šmídová
undergraduate student
Bc. Kateřina Jarosilová
undergraduate student
Simona Krausová
lab technician

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