Intranet Čeština

Biomaterials and Tissue Engineering

Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

•          To improve currently-used synthetic tissue replacements by introducing cell and other biological components

•          To construct completely new replacements on the basis of synthetic materials and cells

To achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Launch of bone tissue engineering

Konstrukce dvojvrstvy lidských keratinocytů (hlavního buněčného typu epidermis) a fibroblastů (hlavního buněčného typu dermis) na nanovlákenných membránách z polylaktidu. More

Publications

Vandrovcová, Marta - Douglas, T.E.L. - Mróz, W. - Musial, O. - Schaubroeck, D. - Budner, B. - Syroka, R. - Dubruel, P. - Bačáková, Lucie . Pulsed laser deposition of magnesium-doped calcium phosphate coatings on porous polycaprolactone scaffolds produced by rapid prototyping . Materials Letters. 2015, Vol. 148, Jun 1, p. 178-183 . IF = 2.489 [ASEP] [ doi ]
Vandrovcová, Marta - Douglas, T.E.L. - Heinemann, S. - Scharnweber, D. - Dubruel, P. - Bačáková, Lucie . Collagen-lactoferrin fibrillar coatings enhance osteoblast proliferation and differentiation . Journal of Biomedical Materials Research. Part A. 2015, Vol. 103, 2, p. 525-533 . IF = 3.369 [ASEP] [ doi ]
Solař, P. - Kylián, O. - Marek, A. - Vandrovcová, Marta - Bačáková, Lucie - Hanuš, J. - Vyskočil, J. - Slavínská, D. - Biederman, H. Particles induced surface nanoroughness of titanium surface and its influence on adhesion of osteoblast-like MG-63 cells . Applied Surface Science. 2015, Vol. 324, Jan 1, p. 99-105 . IF = 2.711 [ASEP] [ doi ]
Posadowska, U. - Pařízek, Martin - Filová, Elena - Wlodarczyk-Biegun, M. - Kamperman, M. - Bačáková, Lucie - Pamula, E. Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate . International Journal of Pharmaceutics. 2015, Vol. 485, 1-2, p. 31-40 . IF = 3.650 [ASEP] [ doi ]
Melnichuk, I. - Choukourov, A. - Bilek, M. - Weiss, A. - Vandrovcová, Marta - Bačáková, Lucie - Hanuš, J. - Kousal, J. - Shelemin, A. - Solař, P. - Slavínská, D. - Biederman, H. Direct covalent coupling of proteins to nanostructured plasma polymers: a route to tunable cell adhesion . Applied Surface Science. 2015, Vol. 351, -, p. 537-545 . IF = 2.711 [ASEP] [ doi ]
Lišková, Jana - Douglas, T.E.L. - Beranová, J. - Skwarczyńska, A. - Božič, M. - Samal, S. K. - Modrzejewska, Z. - Gorgieva, S. - Kokol, V. - Bačáková, Lucie . Chitosan hydrogels enriched with polyphenols: Antibacterial activity, cell adhesion and growth and mineralization . Carbohydrate Polymers. 2015, Vol. 129, -, p. 135-142 . IF = 4.074 [ASEP] [ doi ]
Lišková, Jana - Babchenko, Oleg - Varga, Marián - Kromka, Alexander - Hadraba, Daniel - Švindrych, Zdeněk - Burdíková, Zuzana - Bačáková, Lucie . Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films . International Journal of Nanomedicine. 2015, Vol. 10, 2015, p. 869-884 . IF = 4.383 [ASEP] [ doi ]
Kumorek, Marta Maria - Kubies, Dana - Filová, Elena - Houska, Milan - Kasoju, Naresh - Mázl Chánová, Eliška - Matějka, Roman - Krýslová, Markéta - Bačáková, Lucie - Rypáček, František . Cellular responses modulated by FGF-2 adsorbed on albumin/heparin layer-by-layer assemblies . PLoS ONE. 2015, Vol. 10, 5, e0125484_1-e0125484_23 . IF = 3.234 [ASEP] [ doi ]
Kopová, Ivana - Lavrentiev, Vasyl - Vacík, Jiří - Bačáková, Lucie . Growth and Potential Damage of Human Bone-Derived Cells Cultured on Fresh and Aged C-60/Ti Films . PLoS ONE. 2015, Vol. 10, 4, e0123680 . IF = 3.234 [ASEP] [ doi ]
Brady, M.A. - Renzing, A. - Douglas, T.E.L. - Liu, Q. - Wille, S. - Pařízek, Martin - Bačáková, Lucie - Kromka, Alexander - Jarošová, Markéta - Godier, G. - Warnke, P. H. Development of Composite Poly(Lactide-co-Glycolide)- Nanodiamond Scaffolds for Bone Cell Growth . Journal of Nanoscience and Nanotechnology. 2015, Vol. 15, 2, p. 1060-1069 . IF = 1.556 [ASEP] [ doi ]

Article photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Biomaterials and Tissue Engineering

Vídeňská 1083
14220 Prague 4
tel. +420 241 063 743
 

lucy@biomed.cas.cz

Lucie.Bacakova@fgu.cas.cz

People

Doc. MUDr. Lucie Bačáková, CSc.
head of the department

RNDr. Marta Vandrovcová, Ph.D.
deputy head of the department

Doc. MUDr. Vladislav Mareš, DrSc.
researcher

MUDr. Jaroslav Chlupáč, Ph.D.
researcher

Mgr. Elena Filová, Ph.D.
researcher
Ing. Ondřej Kaplan, Ph.D.
researcher
Věra Lisá, prom. biol.
researcher
Mgr. Jana Lišková, Ph.D.
researcher
RNDr. Jana Musílková, CSc.
researcher
RNDr. Martin Pařízek​, Ph.D.
researcher
RNDr. Lubica Staňková (née. Grausová), Ph.D.
researcher
Ing. Markéta Bačáková
PhD student
Mgr. Antonín Brož
PhD student
Ing. Jana Zárubová (née. Havlíková) 
PhD student
Mgr. Ivana Kopová
PhD student
Mgr. Marie Steinerová
PhD student
  Mgr. Júlia Pajorová
PhD student

MUDr. Martina Trávníčková
PhD student

  Helena Dragounová
pregraduate student
Bc. Nikola Kročilová 
pregraduate student
Bc. Radmila Kudláčková 
pregraduate student
  Anežka Marko
grammar school student
Jana Voborníková
administrative worker
Ivana Zajanová
technician

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