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Experimental Hypertension

Experimental Hypertension

Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:

 

  • Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
  • Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
  • Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
  • Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).

Job vacancies: Leader of the Department of Experimental Hypertension

Projects

Achievements

Publications

Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef . ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood . Physiological Research. 2015, Vol. 64, 3, p. 303-312 . IF = 1.293 [ASEP]
Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Vernerová, Z. - Zicha, Josef . Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet . Journal of Hypertension. 2015, Vol. 33, 1, p. 161-169 . IF = 4.720 [ASEP] [ doi ]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef . Pathogenetic Mechanisms of Neurogenic Pulmonary Edema . Journal of Neurotrauma. 2015, Vol. 32, 15, p. 1135-1145 . IF = 3.714 [ASEP] [ doi ]
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Josef - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří . Stem cells regenerative properties on new rat spinal fusion model . Physiological Research. 2015, Vol. 64, 1, p. 119-128 . IF = 1.293 [ASEP]
Ergang, Peter - Vodička, Martin - Soták, Matúš - Klusoňová, Petra - Behuliak, Michal - Řeháková, Lenka - Zach, P. - Pácha, Jiří . Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats . Psychoneuroendocrinology. 2015, Vol. 53, Mar 2015, p. 49-59 . IF = 4.944 [ASEP] [ doi ]
Brunová, Aneta - Bencze, Michal - Behuliak, Michal - Zicha, Josef . Acute and chronic role of nitric oxide, renin-angiotensin system and sympathetic nervous system in the modulation of calcium sensitization in Wistar Rats . Physiological Research. 2015, Vol. 64, 4, p. 447-457 . IF = 1.293 [ASEP]
Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal . Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene . Physiological Research 2014, roč. 63, 2, p. 263-265. ISSN 0862-8408. IF = 1.293 [ASEP]
Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Vaněčková, Ivana . Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system . Physiological Research 2014, roč. 63, 1, p. 13-26. ISSN 0862-8408. IF = 1.293 [ASEP]
Zicha, Josef - Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Kuneš, Jaroslav - Vaněčková, Ivana . The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats . Physiological Research 2014, roč. 63, suppl.1, s19-s27. ISSN 0862-8408. IF = 1.293 [ASEP]
Vrablík, M. - Dobiášová, Milada - Zlatohlávek, L. - Urbanová, Z. - Češka, R. Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle intervention . Physiological Research. 2014, Vol. 63, 6, p. 745-752 . IF = 1.293 [ASEP]

Article photogallery

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Contacts

Institute of Physiology AS CR, v.v.i.
Department of Experimental Hypertension

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 438
fax. +420 241 062 488
 

zicha@fgu.cas.cz

People

  MUDr. Josef Zicha, DrSc.
head of the department
  RNDr. Jaroslav Kuneš, DrSc.
senior researcher
  RNDr. Milada Dobiášová, DrSc.
senior researcher
  MUDr. Hana Rauchová, CSc.
senior researcher
  RNDr. Ivana Vaněčková, CSc.
senior researcher
  RNDr. Michaela Kadlecová, Ph.D.
junior researcher
  Mgr. Michal Behuliak, Ph.D.
junior researcher
  Mgr. Silvie Hojná, Ph.D.
junior researcher
  RNDr. Lenka Řezáčová, Ph.D.
postdoc
  Mgr. Michal Bencze
PhD student
  Mgr. Anna Loučková
PhD student
  Alena Charvátová
technician
  Zdeňka Kopecká
technician

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