Intranet Čeština

Cellular and Molecular Neuroendocrinology

Cellular and Molecular Neuroendocrinology

Laboratory is focused on the research of membrane receptors and secretion in neuroendocrine cells, with a special emphasis on the interactions between plasma membrane electrical events and receptor-controlled pathways. The Laboratory investigates signaling pathways at the cellular and molecular levels, determines the manner in which hormones and neurotransmitters utilize calcium and cyclic nucleotides as intracellular messengers, and characterizes channels involved in electrical activity, calcium signaling, and release of hormones and neurotransmitters.

 

Main topics:

  • Ion channels and electrical excitability of pituitary cells
  • Purinergic signaling in neurons of suprachiasmatic and supraoptic nuclei of hypothalamus
  • Relationship between structure and function of purinergic P2X receptor-channels

Projects

Achievements

Publications

Zemková, Hana - Khadra, A. - Rokic, Milos Boro - Tvrdoňová, Vendula - Sherman, A. - Stojilkovic, S. S. Allosteric regulation of the P2X4 receptor channel pore dilation . Pflugers Archiv - European Journal of Physiology. 2015, Vol. 467, 4, p. 713-726 . IF = 4.101 [ASEP] [ doi ]
Jindřichová, Marie - Bhattacharya, Anirban - Rupert, Marian - Skopek, Petr - Obšil, T. - Zemková, Hana . Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity . Journal of Neurochemistry. 2015, Vol. 133, 6, p. 815-827 . IF = 4.281 [ASEP] [ doi ]
Zemková, Hana - Tvrdoňová, Vendula - Bhattacharya, Anirban - Jindřichová, Marie . Allosteric modulation of ligand gated ion channels by ivermectin . Physiological Research 2014, roč. 63, suppl.1, s215-s224. ISSN 0862-8408. IF = 1.293 [ASEP]
Tvrdoňová, Vendula - Rokic, Milos Boro - Stojilkovic, S. S. - Zemková, Hana . Identification of Functionally Important Residues of the Rat P2X4 Receptor by Alanine Scanning Mutagenesis of the Dorsal Fin and Left Flipper Domains . PLoS ONE 2014, roč. 9, 11, e112902. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Rokic, Milos Boro - Stojilkovic, S. S. - Zemková, Hana . Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating . Frontiers in Cellular Neuroscience 2014, roč. 8, jan 29, p. 3. ISSN 1662-5102. IF = 4.289 [ASEP] [ doi ]
Bendová, Zdeňka - Janoušková, Hana - Svobodová, Irena . Circadian rhythm and photic induction of the C-terminal splice variant of NMDAR1 subunit in the rat suprachiasmatic nucleus . Synapse 2014, roč. 68, 2, p. 85-88. ISSN 0887-4476. IF = 2.127 [ASEP] [ doi ]
Zemková, Hana - Kučka, M. - Bjelobaba, I. - Tomic, M. - Stojilkovic, S. S. Multiple Cholinergic Signaling Pathways in Pituitary Gonadotrophs . Endocrinology, 2013, Vol. 154, 1, p. 421-433 . IF = 4.717 [ASEP] [ doi ]
Rokic, Milos Boro - Stojilkovic, S. S. - Vávra, Vojtěch - Kuzyk, Pavlo - Tvrdoňová, Vendula - Zemková, Hana . Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor . PLoS ONE, 2013, Vol. 8, 3, e59411 . IF = 3.730 [ASEP] [ doi ]
Khadra, A. - Tomic, M. - Yan, Z. - Zemková, Hana - Sherman, A. - Stojilkovic, S. S. Dual Gating Mechanism and Function of P2X7 Receptor Channels . Biophysical Journal, 2013, Vol. 104, 12, p. 2612-2621 . IF = 3.668 [ASEP] [ doi ]
Bhattacharya, Anirban - Vávra, Vojtěch - Svobodová, Irena - Bendová, Z. - Vereb, G. - Zemková, Hana . Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei . Journal of Neuroscience, 2013, Vol. 33, 18, p. 8035-8044 . IF = 6.908 [ASEP] [ doi ]

Article photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Cellular and Molecular Neuroendocrinology

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 574
fax. +420 241 062 488
 

zemkova@fgu.cas.cz

People

RNDr. Hana Zemková, CSc.
head of the department
  Ing. Irena Svobodová, Ph.D. 
senior researcher
  MUDr. Tomáš Radil, DrSc.​ 
senior researcher
MUDr. Marie Jindřichová, Ph.D. 
senior researcher
Mgr. Vojtěch Vávra, Ph.D.
postdoc (on postdocoral position abroad)
Anirban Bhattacharya, Ph.D.
postdoc 
Mgr. Vendula Stillerová (Tvrdoňová), Ph. D.
postdoc
Ing. Hana Janoušková
lab technician
Irina Kalová
lab technician

© 2014 INSTITUTE OF PHYSIOLOGY CAS