Intranet Čeština

Neurohumoral Regulations

Neurohumoral Regulations Central clock in the brain - the suprachiasmatic nucleus. A cross section of the brain at the level of the hypothalamus is shown. Immunohistochemistry (bright field on the left and fluorescence on the right) was used to detect clock cells.

In the center of our interest is the timing system, biological clock of mammals, including humans. The system ensures temporal coordination of physiological processes in our body so that they take place at the right time of day and are optimally timed.

 

A failure of temporal regulation have a negative impact on human health. We focus on the following questions:

 

  • What are the mechanisms for entraining the timing system in the body and what are the consequences of failure of this mechanism?
  • How does the timing system develop and how is it being entrained during ontogeny?
  • How is the timing system of humans entrained in real life conditions, both in health and in disease?

Projects

The ontogenesis of the biological clock of laboratory rat

The mammalian biological clock initiates its ontogenesis already during embryonic development in the maternal uterus. Newborn mammals are equipped with clock running in accordance with the maternal clock. We focus on investigating when and how do the newborn clock develop and entrain.  More

Achievements

Publications

Olejníková, Lucie - Polidarová, Lenka - Paušlyová, Lucia - Sládek, Martin - Sumová, Alena . Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease . Chronobiology International. 2015, Vol. 32, 4, p. 531-547 . IF = 3.343 [ASEP] [ doi ]
Nováková, Marta - Praško, J. - Látalová, K. - Sládek, Martin - Sumová, Alena . The circadian system of patients with bipolar disorder differs in episodes of mania and depression . Bipolar Disorders. 2015, Vol. 17, 3, p. 303-314 . IF = 4.965 [ASEP] [ doi ]
Houdek, Pavel - Polidarová, Lenka - Nováková, Marta - Matějů, Kristýna - Kubík, Štěpán - Sumová, Alena . Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver . Developmental Neurobiology. 2015, Vol. 75, 2, p. 131-144 . IF = 3.370 [ASEP] [ doi ]
Soták, Matúš - Sumová, Alena - Pácha, Jiří . Cross-talk between the circadian clock and the cell cycle in cancer . Annals of Medicine 2014, roč. 46, 4, p. 221-232. ISSN 0785-3890. IF = 3.886 [ASEP] [ doi ]
Polidarová, Lenka - Olejníková, Lucie - Paušlyová, Lucia - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena . Development and entrainment of the colonic circadian clock during ontogenesis . American Journal of Physiology-Gastrointestinal and Liver Physiology 2014, roč. 306, 4, g346-g356. ISSN 0193-1857. IF = 3.798 [ASEP] [ doi ]
Petrásek, Tomáš - Prokopová, Iva - Sládek, Martin - Weissová, Kamila - Vojtěchová, Iveta - Bahník, Štěpán - Zemanová, Anna - Schönig, K. - Berger, S. - Tews, B. - Bartsch, D. - Schwab, M. E. - Sumová, Alena - Stuchlík, Aleš . Human osteoblast-like MG 63 cells on polysulfone modified with carbon nanotubes or carbon nanohorns . Frontiers in Behavioral Neuroscience 2014, roč. 8, mar 18, p. 90. ISSN 1662-5153. IF = 3.27 [ASEP] [ doi ]
Nováková, Marta - Sumová, Alena . New methods to assess circadian clocks in humans . INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 2014, roč. 52, 5, p. 404-412. ISSN 0019-5189. IF = 0.835 [ASEP]
Houdek, Pavel - Sumová, Alena . In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei . PLoS ONE 2014, roč. 9, 9, e107360. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Bendová, Zdeňka - Janoušková, Hana - Svobodová, Irena . Circadian rhythm and photic induction of the C-terminal splice variant of NMDAR1 subunit in the rat suprachiasmatic nucleus . Synapse 2014, roč. 68, 2, p. 85-88. ISSN 0887-4476. IF = 2.127 [ASEP] [ doi ]
Zhang, L. - Hastings, M. H. - Green, E. W. - Tauber, E. - Sládek, Martin - Webster, S. G. - Kyriacou, C. P. - Wilcockson, D. C. Dissociation of Circadian and Circatidal Timekeeping in the Marine Crustacean Eurydice pulchra . Current Biology, 2013, Vol. 23, 19, p. 1863-1873 . IF = 9.494 [ASEP] [ doi ]

Article photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Neurohumoral Regulations

Vídeňská 1083
14220 Prague 4
Czech Republic
tel. +420 241 062 528
fax. +420 241 062 488
 

sumova@fgu.cas.cz

sladek@fgu.cas.cz

People

PharmDr. Alena Sumová, DSc.

head of the department

Martin Sládek, PhD.
deputy head of the department

Prof. Helena Illnerová, DrSc.
senior researcher
 
Lenka Polidarová
postdoc
 
 
Pavel Houdek

researcher

 

Zuzana Novosadová

PhD student

 
Karolína Suchmanová
student
 
 

Petra Honzlová

student

 

Barbora Černá

student

  Lucie Heppnerová
technician
  Eva Suchanová
technician

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