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Neurochemistry

Neurochemistry

We study the physiology, biochemistry and pharmacology of cholinergic neurons at molecular level. In our study we mainly employ cell lines but we also use animal models. Our research is focused mainly on these topics:

 

  • Biochemical physiology and pharmacology of cholinergic neurons. Development and differentiation of cholinergic neurons. Synthesis, storage, and release of acetylcholine. Presynaptic regulation of acetylcholine release.
  • Cholinergic mechanisms in pathogenesis of Alzheimer´s disease. Influence of beta-amyloid on acetylcholine metabolism and muscarinic transmission.
  • Molecular pharmacology of muscarinic receptors. Allosteric modulation of receptor activation. Interaction of muscarinic receptors with G-proteins. Modeling of muscarinic receptor signal transduction.

 

Job vacancies:.Leader of the Department of Neurochemistry

Projects

Achievements

Publications

Article photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Neurochemistry

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 287
fax. +420 241 062 488
   

jakubik@biomed.cas.cz

People

  Mgr. Jan Jakubík, Ph.D.
head of the department
  MUDr. Vladimír Doležal, DrSc.
senior researcher
  PharmDr. Ing. Pavel Michal, Ph.D.
senior researcher
  RNDr. Vladimír Rudajev Ph.D.
senior researcher
  RNDr. Vladimír Rudajev Ph.D.
senior researcher
  Glenda Paola Barrera Alquicer, Ph.D.
postdoc
  MUDr. Mgr. Helena Janíčková, Ph.D.
postdoc
  Mgr. Eva Machová, Ph.D.
postdoc
  Mgr. Alena Randáková
PhD student
  Mgr. Eva Šantrůčková
PhD student
  Bc. et Mgr. Pavel Zimčík
PhD student
  Romana Ondřejová
technician
  Dana Ungerová
technician
  Jana Voborníková
technician

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