Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:
- Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
- Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
- Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
- Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).
Projects
Achievements
Publications
Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
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Oxidative Medicine and Cellular Longevity. 2016, roč. 2016, 2016, p. 9814038
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IF = 4.492
[ASEP]
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doi
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Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Loukotová, Jana - Nováková, O. - Kuneš, Jaroslav - Zicha, Josef
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The influence of erythrocyte maturity on ion transport and membrane lipid composition in the rat
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Physiological Research. 2016, roč. 65, 1, p. 91-99
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IF = 1.618
[ASEP]
Mikulášková, Barbora - Zemenová, J. - Pirník, Z. - Pražienková, V. - Bednárová, L. - Železná, B. - Maletínská, L. - Kuneš, Jaroslav
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Effect of palmitoylated prolactin-releasing peptide on food intake and neural activation after different routes of peripheral administration in rats
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Peptides. 2016, roč. 75, Jan, p. 109-117
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IF = 2.535
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doi
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Lettrichová, I. - Tóthová, L. - Hodosy, J. - Behuliak, Michal - Celec, P.
Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
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Redox Report. 2016, roč. 21, 1, p. 24-30
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IF = 2.606
[ASEP]
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doi
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Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
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NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats
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Physiological Research. 2015, Vol. 64, 6, p. 849-856
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IF = 1.618
[ASEP]
Kuneš, Jaroslav - Vaněčková, Ivana - Mikulášková, Barbora - Behuliak, Michal - Maletínská, L. - Zicha, Josef
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Epigenetics and a new look on metabolic syndrome
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Physiological Research. 2015, Vol. 64, 5, p. 611-620
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IF = 1.618
[ASEP]
Brunová, Aneta - Bencze, Michal - Behuliak, Michal - Zicha, Josef
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Acute and chronic role of nitric oxide, renin-angiotensin system and sympathetic nervous system in the modulation of calcium sensitization in Wistar Rats
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Physiological Research. 2015, Vol. 64, 4, p. 447-457
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IF = 1.618
[ASEP]
Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
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ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood
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Physiological Research. 2015, Vol. 64, 3, p. 303-312
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IF = 1.618
[ASEP]
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Josef - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
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Stem cells regenerative properties on new rat spinal fusion model
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Physiological Research. 2015, Vol. 64, 1, p. 119-128
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IF = 1.618
[ASEP]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
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Pathogenetic Mechanisms of Neurogenic Pulmonary Edema
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Journal of Neurotrauma. 2015, Vol. 32, 15, p. 1135-1145
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IF = 4.377
[ASEP]
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doi
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Show more
Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
