Organic Chemistry

The project is focused on the synthesis of so far unknown nucleoside and nucleotide analogs in deoxy and ribo series, which contain a heterocyclus with one and two heteroatoms instead of the pentofuranose ring. Heterocyclus is quite isosteric with pentofuranose ring. A key modification concerns the original C4' position. New synthetic approaches will be elaborated in the chemistry of phosphonic and phosphinic acids using modern synthetic methods, e.g. metathesis. All prepared final compounds will be subjected to the conformational analysis which should reveal the changes in nucleobase and pseudo-sugar ring conformation. A biological evaluation of nucleoside and nucleotide analogs will be done in collaboration with our partners.