2000

Krejčová R., Horská K., Votruba I., Holý A.:
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Biochemical Pharmacology 12 (60): 1907-1913, 2000.

Česnek M., Hocek M., Holý A.:
Synthesis of acyclic nucleotide analogues derived from 2-amino-6-C-substituted purines via cross-coupling reactions of 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with diverse organometallic reagents.
Collection of Czechoslovak Chemical Communications 8 (65): 1357-1373, 2000.

Kampf G., Luth M.S., Muller J., Holý A., Lippert B., Sigel H.:
Properties of the ternary (Dien)Pt(PMEA-N7) complex containing diethylenetriamine (Dien) and the antiviral 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Synthesis, biological screening, acid-base behaviour, and metal ion-binding in aqueous solution.
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 12 (55): 1141-1152, 2000.

Janeba Z., Holý A., Masojídková M.:
Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one.
Collection of Czechoslovak Chemical Communications 7 (65): 1126-1144, 2000.

Zídek Z., Franková D., Holý A.:
Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli.
International Journal of Immunopharmacology 12 (22): 1121-1129, 2000.

Gomez-Coca R.B., Kapinos L.E., Holý A., Vilaplana R.A., Gonzalez-Vilchez F., Sigel H.:
Ternary copper(II) complexes in solution[1,2] formed with 8-AZA derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Metal-Based Drugs 6 (7): 313-324, 2000.

Meszarosova K., Holý A., Masojídková M.:
Synthesis of acyclic adenine 8,N-anhydronucleosides.
Collection of Czechoslovak Chemical Communications 7 (65): 1109-1125, 2000.

Gomez-Coca R.B., Kapinos L.E., Holý A., Vilaplana R.A., Gonzalez-Vilchez F., Sigel H.:
Metal ion-binding properties of 9-(4-phosphonobutyl)adenine (dPMEA), a sister compound of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), and quantification of the equilibria involving four Cu(PMEA) isomers.
Journal of the Chemical Society, Dalton Transactions 2000 (13): 2077-2084.

Hřebabecký H., Holý A.:
Synthesis of carbocyclic 4´-C-hydroxymethyl analogues of azidodeoxythymidine, deoxythymidine, deoxydidehydrothymidine and thymidine carba analogue with fused oxetane ring.
Collection of Czechoslovak Chemical Communications 3 (65): 395-406, 2000.

Hocek M., Holý A., Votruba I., Dvořáková H.:
Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-D-erythro-pentofuranosyl)-, 9-(5-deoxy-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines.
Collection of Czechoslovak Chemical Communications 11 (65): 1683-1697, 2000.

Janeba Z., Holý A., Masojídková M.:
Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purine-8(9H)-thione and 8-(methylsulfanyl)adenine.
Collection of Czechoslovak Chemical Communications 11 (65): 1698-1712, 2000.

Alexander P., Holý A., Buděšínský M., Masojídková M.:
Synthesis of acyclic nucleotide analogues derived from N3-substituted isoguanine.
Collection of Czechoslovak Chemical Communications 11 (65): 1713-1725, 2000.

Krejčová R., Horská K., Votruba I., Holý A.:
Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells.
Collection of Czechoslovak Chemical Communications 10 (65): 1653-1668, 2000.

Kovařík A., Van Houdt H., Holý A., Depicker A.:
Drug-induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing.
FEBS Letters 1 (467): 47-51, 2000.

Hocek M., Holý A., Votruba I., Dvořáková H.:
Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.
Journal of Medicinal Chemistry 9 (43): 1817-1825, 2000.

Bobková K., Otová B., Marinov I., Mandys V., Panczak A., Votruba I., Holý A.:
Anticancer effect of PMEDAP - Monitoring of apoptosis.
Anticancer Research 2 A (20): 1041-1047, 2000.