2008

Vavrová K., Lorencová K., Novotný J., Holý A., Hrabálek A.:
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH ion-pairing and skin species.
European Journal of Pharmaceutics and Biopharmaceutics 70: 901-907 2008.

Anzenbacherová E., Anzenbacher P., Zidek Z., Buchar E., Kmoničková E., Potměšil P., Nekvindová J., Veinlichová A., Holý A.:
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Physiological Research (Prague Czech Republic) 57: 761-767 2008.

Gammon D. B., Snoeck R., Fiten P., Krečmerová M., Holý A., De Clercq E., Opdenakker G., Evans D. H., Andrei G.:
Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs
J. Virol. 82: 12520-12534 2008.

Renders M., Lievrouw R., Krečmerová M., Holý A., Herdewijn P.:
Enzymatic polymerization of phosphonate nucleosides
ChemBioChem 9: 2883-2888 2008.

Naesens L., Andrei G., Votruba I., Krečmerová M., Holý A., Neyts J., De Clercq E., Snoeck R.:
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
Biochem. Pharmacol. 76: 997-1005 2008.

Votruba I., Otová B., Holý A.:
Acyklické nukleosidfosfonáty jako potenciální antineoplastika
Čas. Lék. čes. 147: 471-477 2008.

Česnek M., Holý A., Masojídkova M., Kmoníčkova E., Zídek Z.:
Synthesis of guanidino analogues of PMPDAP and their immunobiological activity
Bioorg. Med. Chem. 16: 965-980 2008.

Dračínský M., Krečmerová M., Holý A.:
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy
Bioorg. Med. Chem. 16: 6778-6782 2008.

Schinkmanová M., Votruba I., Shibata R., Han B., Liu X., Cihlář T., Holý A.:
Human N⁶-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N⁶-substituted purine acyclic nucleoside phosphonates
Collect. Czech. Chem. Commun. 73: 275-291 2008.

Pomeisl K., Holý A., Votruba I., Pohl R.:
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase
Bioorg. Med. Chem. Lett. 18: 1364-1367 2008.

Hájek M., Votruba I., Holý A., Krečmerová M., Tloušťová E.:
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells
Biochem. Pharmacol. 75: 965-972 2008.

Hřebabecký H., Dračínský M., Holý A:
Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol
Collect. Czech. Chem. Commun. 73: 44-58 2008.

Vávrová K., Lorencová K., Klimentová J., Novotný J., Holý A., Hrabálek A.:
Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers
Eu. J. Pharm. Biopharm. 69: 597-604 2008.