Biochemistry

The project will be conducted at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Pavlina Rezacova (www.uochb.cz/rezacova).  Project focuses on structural studies of therapeutically relevant isoenzymes of human carbonic anydrase. Structural information will be used for design of isoform specific inhibitors. The work on this project provides the opportunity to acquire an expertise in protein biochemistry, biophysics and structural biology, as well as to get an insight into the rational drug design process through a close collaboration with the medicinal and computational chemistry research teams.