The research at our departments focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.
Our primary research topics are:
- Consequences of brain injury during early stages of the brain development
- Mechanisms responsible for seizure initiation and termination.
- Impact of seizures on the developing brain
- Development of new diagnostic techniques of epilepsy
- Cognitive and behavioural consequences of epilepsy
- The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
- Impact of antiepileptic therapy of the brain development
- Age-specific mechanisms of seizure initiation and propagation
Projects
Brain-damaging insult triggers a cascade of molecular, cellular and structural changes that eventually lead to behavioral alterations and development of epilepsy. The response to the particular brain insult is highly age-dependent. Our aim is to study effects of early insults on the brain development at the molecular, cellular, and circuitry levels (maturation of receptors or ionic channel structures, vascularisation, myelination, circuitry maturation, etc.) and consequently on maturation of more complex brain functions (cognitive functions, sensorimotor skills, social and emotional behavior, brain excitability, etc.). Results of our research can be used to develop age specific pharmacological strategies for prevention of epilepsy development and disturbances of brain function.
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Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of many neurological disorders, including epilepsy.
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The main aim of this research is to develop new diagnostic techniques to increase the information yield of presurgical examination and to improve the outcome of epilepsy surgery.
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Seizures represent the main symptom of epilepsy.
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Incidence of behavioral abnormities, cognitive impairment and mental problems is higher in some forms of epilepsy than in healthy population.
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Achievements
Epileptology European Award 2016 was awarded prof. Pavel Mareš.
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Publications
Tykalová, T. - Pospíšilová, M. - Čmejla, R. - Jeřábek, J. - Mareš, Pavel - Rusz, J.
Speech changes after coordinative training in patients with cerebellar ataxia: a pilot study
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Neurological Sciences. 2016, roč. 37, 2, p. 293-296
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IF = 1.783
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Kasal, Alexander - Buděšínský, Miloš - Mareš, Pavel - Krištofíková, Z. - Leitao, A. J. - Sá e Melo, M. L. - Silva, M. M. C.
Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?
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Steroids. 2016, roč. 105, Jan, p. 12-18
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IF = 2.513
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Fábera, Petr - Krijtová, H. - Tomášek, M. - Krýsl, D. - Zámečník, J. - Mohapl, M. - Jiruška, Přemysl - Marusič, P.
Familial temporal lobe epilepsy due to focal cortical dysplasia type IIIa
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Seizure-European Journal of Epilepsy. 2015, Vol. 31, -, p. 120-123
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IF = 2.109
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Suchomelová, L. - Lopes-Meraz, M. L. - Niquet, J. - Kubová, Hana - Wasterlain, C. G.
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats
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Neuroscience. 2015, Vol. 305, Oct 1, p. 209-224
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IF = 3.231
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Mareš, Pavel - Kubová, Hana
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GABA(B), not GABA(A) receptors play a role in cortical postictal refractoriness
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Neuropharmacology. 2015, Vol. 88, Jan 2015, p. 99-102
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IF = 4.936
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Pošusta, Antonín - Sporka, A. J. - Poláček, O. - Rudolf, Š. - Otáhal, Jakub
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Control of word processing environment using myoelectric signals
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Journal on Multimodal User Interfaces. 2015, Vol. 9, 4, p. 299-311
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IF = 1.017
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doi
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Druga, Rastislav - Salaj, M. - Barinka, F. - Edelstein, L. - Kubová, Hana
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Calretinin immunoreactivity in the claustrum of the rat
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Frontiers in Neuroanatomy. 2015, Vol. 8, Jan 20, p. 160
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IF = 3.26
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Tsenov, Grygoriy - Vondráková, Kateřina - Otáhal, Jakub - Burchfiel, J. - Kubová, Hana
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Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats
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Experimental Neurology. 2015, Vol. 265, Mar 2015, p. 40-47
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IF = 4.657
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Szczurowska, Ewa - Mareš, Pavel
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An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats?
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Epilepsy Research. 2015, Vol. 109, Jan 2015, p. 106-113
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IF = 2.237
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Rektor, I. - Schachter, S.C. - Arya, R. - Arzy, S. - Braakman, H. - Brodie, M.J. - Brugger, P. - Chang, B. S. - Guekht, A. - Hermann, B. - Hesdorffer, D. C. - Jones-Gotman, M. - Kanner, A.M. - Garcia-Larrea, L. - Mareš, Pavel - Mula, M. - Neufeld, M. - Risse, G. L. - Ryvlin, P. - Seeck, M. - Tomson, T. - Korczyn, A.D.
Third International Congress on Epilepsy, Brain, and Mind: Part 2
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Epilepsy and Behavior. 2015, Vol. 50, Sep 2015, p. 138-159
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IF = 2.332
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