Intranet Čeština

Cardiovascular Morphogenesis

Cardiovascular Morphogenesis Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.

We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:

  • Study of influence epigenetic factors on heart development.
  • Analysis of mechanisms of embryonic heart failure.
  • Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
  • Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.

These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.

Projects

Achievements

Publications

Pérez-Pomares, J. M. - de la Pompa, J. L. - Franco, D. - Henderson, D. - Ho, S. Y. - Houyel, L. - Kelly, R. G. - Sedmera, David - Sheppard, M. - Sperling, S. - Thiene, G. - van den Hoff, M. - Basso, C. Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group . Cardiovascular Research. 2016, roč. 109, 2, p. 204-216 . IF = 5.465 [ASEP] [ doi ]
Sedmera, David - Kočková, Radka - Vostárek, František - Raddatz, E. Arrhythmias in the developing heart . Acta Physiologica. 2015, Vol. 213, 2, p. 303-320 . IF = 4.066 [ASEP] [ doi ]
Vostárek, František - Šaňková, Barbora - Sedmera, David . Studying dynamic events in the developing myocardium . Progress in Biophysics & Molecular Biology. 2014, roč. 115, 2-3, p. 261-269. ISSN 0079-6107. IF = 2.274 [ASEP] [ doi ]
Tenin, G. - Clowes, Ch. - Wolton, K. - Krejčí, Eliška - Wright, J. A. - Lovell, S. C. - Sedmera, David - Hentges, K. E. Erbb2 Is Required for Cardiac Atrial Electrical Activity during Development . PLoS ONE. 2014, roč. 9, 9, e107041. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Sochman, J. - Peregrin, J.H. - Pavcnik, D. - Uchida, B.T. - Timmermans, H.A. - Sedmera, David - Benada, Oldřich - Kofroňová, Olga - Keller, F.S. - Rosch, J. Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study . Physiological Research 2014, roč. 63, 2, p. 157-165. ISSN 0862-8408. IF = 1.293 [ASEP]
Sedmera, David - Gourdie, R. G. Why do we have Purkinje fibers deep in our heart? . Physiological Research 2014, roč. 63, suppl.1, s9-s18. ISSN 0862-8408. IF = 1.293 [ASEP]
Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Sedmera, David . Developmental determinants of cardiac sensitivity to hypoxia . Canadian Journal of Physiology and Pharmacology 2014, roč. 92, 7, p. 566-574. ISSN 0008-4212. IF = 1.77 [ASEP] [ doi ]
Hejnová, L. - Hahnová, K. - Kočková, Radka - Svatůňková, Jarmila - Sedmera, David - Novotný, J. Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs . BioMed Research International. 2014, roč. 2014, 2014, p. 463123. ISSN 2314-6133. IF = 1.579 [ASEP] [ doi ]
Haque, A. - Šaňková, Barbora - Kvasilová, A. - Krejčí, Eliška - Sedmera, David . Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos? . Folia Biologica. 2014, roč. 60, 5, p. 243-251. ISSN 0015-5500. IF = 1 [ASEP]
Beneš Jr., Jiří - Ammirabile, G. - Šaňková, Barbora - Campione, M. - Krejčí, Eliška - Kvasilová, A. - Sedmera, David . The role of connexin40 in developing atrial conduction . FEBS Letters 2014, roč. 588, 8, p. 1465-1469. ISSN 0014-5793. IF = 3.169 [ASEP] [ doi ]

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Contacts

Institute of Physiology AS CR, v.v.i.
Department of Cardiovascular Morphogenesis

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 561
fax. +420 241 062 125
   

david.sedmera@fgu.cas.cz

People

Prof. MUDr. David Sedmera, D.Sc.
senior scientist
  Mgr. Barbora Šaňková
PhD student
MUDr. Radka Kočková
PhD student
MUDr. Živorad Peševski
PhD student
Mgr. František Vostárek
PhD student
Ing. Eliška Krejčí, Ph.D.
technician
Jarmila Svatůňková
technician

© 2014 INSTITUTE OF PHYSIOLOGY CAS