Organic Chemistry

The new nucleophilic organocatalysts will be prepared starting from diethyl malonimidate or its 2-substituted congeners by condensation thereof with chiral diamines prepared from natural aminoacids. The resulting chiral building blocks, 1,1-bis[(4S)-4-alkyl-4,5-dihydro-1H-imidazol-2-yl]alkanes will be transformed into the new zwitterionic nucleophilic organocatalysts whose structure and properties will be investigated in the course of the project. The catalytic activity and potential of the new organocatalysts will be tested for asymmetric addition reactions of silylated nucleophiles: Me3SiCF3, Me3SiCN, trimethylsilyl enol ethers (Mukaiyama aldol reaction) etc. to carbonyl group of aldehydes and ketones.