Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.
We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:
- Study of influence epigenetic factors on heart development.
- Analysis of mechanisms of embryonic heart failure.
- Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
- Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.
These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.
Projects
Achievements
Publications
Pérez-Pomares, J. M. - de la Pompa, J. L. - Franco, D. - Henderson, D. - Ho, S. Y. - Houyel, L. - Kelly, R. G. - Sedmera, David - Sheppard, M. - Sperling, S. - Thiene, G. - van den Hoff, M. - Basso, C.
Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group
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Cardiovascular Research. 2016, roč. 109, 2, p. 204-216
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IF = 5.465
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doi
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Sedmera, David - Kočková, Radka - Vostárek, František - Raddatz, E.
Arrhythmias in the developing heart
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Acta Physiologica. 2015, Vol. 213, 2, p. 303-320
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IF = 4.066
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doi
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Vostárek, František - Šaňková, Barbora - Sedmera, David
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Studying dynamic events in the developing myocardium
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Progress in Biophysics & Molecular Biology. 2014, roč. 115, 2-3, p. 261-269. ISSN 0079-6107.
IF = 2.274
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doi
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Tenin, G. - Clowes, Ch. - Wolton, K. - Krejčí, Eliška - Wright, J. A. - Lovell, S. C. - Sedmera, David - Hentges, K. E.
Erbb2 Is Required for Cardiac Atrial Electrical Activity during Development
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PLoS ONE. 2014, roč. 9, 9, e107041. ISSN 1932-6203.
IF = 3.234
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doi
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Sochman, J. - Peregrin, J.H. - Pavcnik, D. - Uchida, B.T. - Timmermans, H.A. - Sedmera, David - Benada, Oldřich - Kofroňová, Olga - Keller, F.S. - Rosch, J.
Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study
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Physiological Research 2014, roč. 63, 2, p. 157-165. ISSN 0862-8408.
IF = 1.293
[ASEP]
Sedmera, David - Gourdie, R. G.
Why do we have Purkinje fibers deep in our heart?
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Physiological Research 2014, roč. 63, suppl.1, s9-s18. ISSN 0862-8408.
IF = 1.293
[ASEP]
Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Sedmera, David
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Developmental determinants of cardiac sensitivity to hypoxia
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Canadian Journal of Physiology and Pharmacology 2014, roč. 92, 7, p. 566-574. ISSN 0008-4212.
IF = 1.77
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doi
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Hejnová, L. - Hahnová, K. - Kočková, Radka - Svatůňková, Jarmila - Sedmera, David - Novotný, J.
Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs
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BioMed Research International. 2014, roč. 2014, 2014, p. 463123. ISSN 2314-6133.
IF = 1.579
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doi
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Haque, A. - Šaňková, Barbora - Kvasilová, A. - Krejčí, Eliška - Sedmera, David
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Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos?
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Folia Biologica. 2014, roč. 60, 5, p. 243-251. ISSN 0015-5500.
IF = 1
[ASEP]
Beneš Jr., Jiří - Ammirabile, G. - Šaňková, Barbora - Campione, M. - Krejčí, Eliška - Kvasilová, A. - Sedmera, David
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The role of connexin40 in developing atrial conduction
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FEBS Letters 2014, roč. 588, 8, p. 1465-1469. ISSN 0014-5793.
IF = 3.169
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doi
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Živorad Peševski (2012)
František Vostárek (2013)
