People

Name Mareš Michael
Position Head of the Senior Research Group
Michael Mareš, Ph.D.

Michael Mareš, Ph.D.

Head of the Team


Cathepsin Proteases in Pathology
Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Phone: (+420) 220 183 358
Fax: (+420) 220 183 578

 

 
Education
1987-1991 Ph.D. in biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague.
1981-1986 M.Sc. in biochemistry, Charles University, Prague, Czech Republic.
 
Experience
1996-1998 (18 months) Oklahoma Medical Research Foundation, Oklahoma City, USA.
1994 (2 months) Laboratory of Molecular Biophysics, Oxford University, UK.
1992 (3 months) European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
1991-1995 (8 months) Münster University, Germany.
 
Appointments
since 2007 Head of the IOCB Research Team (Cathepsin Proteases in Pathology).
2003-2006 Head of the Laboratory of Regulation of Proteolysis at IOCB.
2001-2006 Postdoctoral Fellow, Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic.
since 1991 Researcher, Institute of Organic Chemistry and Biochemistry (IOCB), Academy of Sciences of the Czech Republic, Prague.
 
Research interest

Proteases and their regulation in pathological processes, cathepsin proteases in cancer, digestive proteolysis in blood-feeding parasites, allergenic proteases, plant protease inhibitors as insecticides.


Proteomics, protein 3D structures and structure-activity relationship, rational and combinatorial design of small bioactive molecules as chemotherapeutic agents.