Organic Chemistry

Tutor	Ing. Ivan Rosenberg, CSc.
Team	Ivan Rosenberg
Topic	Synthesis of conformationally constrained phosphonate nucleotides as inhibitors of human 5'(3')-nucleotidases
Faculty	FCHT
Abstract	Project is directed towards the synthesis of structuraly diverse conformationally constrained phosphonate nucleotides as a pool of compouds for SAR study with the aim to understand more deeply the key factors influencing selectivity of nucleotidase inhibitors.