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Dr. Karel Koberna
Institute of Molecular and Translational Medicine, Faculty of Medicine & Dentistry, Palacky University, Olomouc, CR
Cytidine deaminase detection, DNA repair enzymes.
Dr. David Staněk
Institute of Molecular Genetics, Acad. Sci., v.v.i., Prague, CR
Evaluation of Phosphonate Analogues of siRNAs.
Prof. Josef Štěpánek
Division of Biomolecular Physics, Faculty of Mathematic and Physics, Charles University, Prague, CR
Raman spectroscopy study on phosphonate oligonucleotides, and their secondary and tertiary structures including, MD study, ab initio calculation, etc.
Dr. Jiří Homola
Institute of Photonics and Electronics, AS, v.v.i., Prague, CR
Surface plasmon resonance study on hybridization of phosphonate oligonucleotides
Dr. S.M. Gryaznov
Alios Biopharma, California, USA
Evaluation of Phosphonate CpG oligonucleotides.
Dr. Dianne Keough and Dr. Luke Guddat
The University of Queensland, Brisbane, Australia
Novel phosphonate aza-nucleotides: Search for selective inhibitors of hypoxanthine-xanthine-guanine-phosphoribosyl transferase from Plasmodium falciparum as potential antimalaric agents.
Dr. Menico Rizzi
DiSCAFF, University of Piemonte Orientale "A. Avogadro", Novara, Italy
Structural analysis of adducts of proteins with oligonucleotides.
Dr. V. Hauryliuk
University of Tartu, Institute of Technology, Tartu, Estonia / Umea University, the Laboratory for Molecular Infection Medicine Sweden, Umea, Sweden
Testing ppGpp analogues in cell-free SR and translational assays15, as well as on the SR in living bacterial cells using HPLC and single-molecule microscopy-based assays.
Dr. Y. Tozawa
Division of Biomolecular Engineering, Ehime University, Japan
Performing X-ray investigations RSH proteins complexed with inhibitors.
Dr. J. Lemos
Microbiology and Immunology / Center for Oral Biology, University of Rochester, USA
Performing in vitro tests of the efficiency of inhibitors against single-domain ribosome-independent RSHs.
Dr. V. Shingler
Umea University, the Laboratory for Molecular Infection Medicine Sweden, Umea, Sweden
Testing ppGpp analogues in E. coli cell-free and cellular transcription assays using a set of ppGpp-activated and ppGpp-inhibited promoters.
Dr. D. Wilson
Gene Center and Department of Chemistry and Biochemistry, Ludwig-Maximilians-University of Munich, Germany
Performing cryoEM investigations of RSHs in associated with ribosomal complexes in the presence of inhibitors. Ribosomal complexes are to be generated in Wilson and Hauryliuk laboratories.
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