2001
Holý A., Otová B., Buděšínský M., Emerson D., Wiles M.E.:
O-phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Journal of Medicinal Chemistry 25 (44): 4462-4467, 2001.
Otmar M., Masojídková M., Votruba I., Holý A.:
An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives.
Collection of Czechoslovak Chemical Communications 3 (66): 500-506, 2001.
Hocek M., Holý A., Votruba I., Dvořáková H.:
Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl-
and 6-benzylpurine ribonucleosides.
Collection of Czechoslovak Chemical Communications 3 (66): 483-499, 2001.
Otmar M., Poláková L., Masojídková M., Holý A.:
A facile synthesis of azetidin-2-ylphosphonic acid and its 1-alkyl derivatives.
Collection of Czechoslovak Chemical Communications 3 (66): 507-516, 2001.
Janeba Z., Holý A., Masojídková M.:
Synthesis of 8-amino-and N-substituted 8-aminoadenine derivatives of acyclic nucleoside and nucleotide analogs.
Collection of Czechoslovak Chemical Communications 3 (66): 517-532, 2001.
Hřebabecký H., Holý A.:
Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-hexopyranoses, intermediates in the synthesis of carbocyclic nucleosides.
Collection of Czechoslovak Chemical Communications 5 (66): 785-798, 2001.
Janeba Z., Holý A., Masojídková M.:
Transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to 6-amino-7H-purin-8(9H)-one derivatives.
Collection of Czechoslovak Chemical Communications 9 (66): 1393-1406, 2001.
Birkus G., Votruba I., Otmar M., Holý A.:
Interactions of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)-propyl]cytosine (cidofovir) diphosphate with DNA polymerases α, δ and ε.
Collection of Czechoslovak Chemical Communications 11 (66): 1698-1706, 2001.
Holý A., Votruba I., Tloušťová E., Masojídková M.:
Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, 2,6-diaminopurines and related compounds.
Collection of Czechoslovak Chemical Communications 10 (66): 1545-1592, 2001.
Janeba Z., Holý A.:
Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases.
Nucleosides, Nucleotides and Nucleic Acids 4-7 (20): 1103-1106, 2001.
Paleta O., Duda Z., Holý A.:
New fluorinated nucleoside analogues with 2-butenolide rings prepared by nucleophilic vinylic fluorine displacement in 4,4-dialkyl-2,3-difluorobut-2-en-4-olides.
Mendeleev Communications 1 (11): 17-19, 2001.
Kapinos L.E., Holý A., Gunter J., Sigel H.:
Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole(=6,9-dimethyl-1,3-dideazapurine). Quantification of the steric effect of the 6-amino group on metal ion binding at the N7 site of the adenine residue.
Inorganic Chemistry 11 (40): 2500-2508, 2001.
Kampf G., Luth M.S., Kapinos L.E., Muller J., Holý A., Lippert B., Sigel H.:
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA): Comparison of the acid-base and metal-ion-binding properties of PMEA, (Dien)Pt(PMEA-N1), and (Dien)Pt(PMEA-N7).
Chemistry - A European Journal 9 (7): 1899-1908, 2001.
Gomez-Coca R.B., Kapinos L.E., Holý A., Vilaplana R.A., Gonzalez-Vilchez F., Sigel H.:
Intramolecular stacking interactions in ternary copper(II) complexes1 formed with 2,2´-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Journal of Inorganic Biochemistry 1-2 (84): 39-46, 2001.
Zídek Z., Franková D., Holý A.:
Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1) production.
Antimicrobial Agents and Chemotherapy 12 (45): 3381-3386, 2001.
Bobková K., Gut I., Mandys V., Holý A., Votruba I., Otová B.:
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the prague inbred Sprague-Dawley/Cub rat strain bearing T-cell lymphoma.
Anticancer Research 4 A (21): 2725-2731, 2001.
Valeriánová M., Votruba I., Holý A., Mandys V., Otová B.:
Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma.
Anticancer Research 3 B (21): 2057-2064, 2001.