Oddělení experimentální hypertenze se věnuje studiu mechanizmů, které se podílejí na regulaci krevního tlaku a na vzniku orgánového poškození u potkanů s různými formami experimentální hypertenze. Hlavní oblasti našeho současného výzkumu jsou:
- Objasnění podílu endotelinového a renin-angiotenzinového systému při vzniku renálního poškození u transgenních potkanů s vloženým myším reninovým genem (Ren-2 TGR) – spolupráce s IKEM.
- Porovnání úlohy vápníkové senzitizace (Rho kinázová dráha) a vápníkového influxu v rozvoji vysokého krevního tlaku u genetické a solné hypertenze potkana – molekulárně biologická analýza poruch těchto regulačních drah.
- Studium centrálních mechanismů regulace krevního tlaku u potkanů s genetickou hypertenzí se zřetelem k mozkovému renin-angiotensinovému systému, centrálním účinkům kortikoidů, baroreflexní kontrole sympatického tonu a oxidačnímu stresu.
- Zkoumání kardiovaskulárních účinků nových analogů neuropeptidů regulujících příjem potravy u potkanů – spolupráce s UOCHB AV ČR.
Aktuální projekty
Úspěchy
Publikace
Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
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Oxidative Medicine and Cellular Longevity. 2016, roč. 2016, 2016, p. 9814038
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IF = 4.492
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doi
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Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Loukotová, Jana - Nováková, O. - Kuneš, Jaroslav - Zicha, Josef
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The influence of erythrocyte maturity on ion transport and membrane lipid composition in the rat
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Physiological Research. 2016, roč. 65, 1, p. 91-99
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IF = 1.618
[ASEP]
Mikulášková, Barbora - Zemenová, J. - Pirník, Z. - Pražienková, V. - Bednárová, L. - Železná, B. - Maletínská, L. - Kuneš, Jaroslav
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Effect of palmitoylated prolactin-releasing peptide on food intake and neural activation after different routes of peripheral administration in rats
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Peptides. 2016, roč. 75, Jan, p. 109-117
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IF = 2.535
[ASEP]
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doi
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Lettrichová, I. - Tóthová, L. - Hodosy, J. - Behuliak, Michal - Celec, P.
Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
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Redox Report. 2016, roč. 21, 1, p. 24-30
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IF = 2.606
[ASEP]
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doi
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Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
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NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats
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Physiological Research. 2015, Vol. 64, 6, p. 849-856
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IF = 1.618
[ASEP]
Kuneš, Jaroslav - Vaněčková, Ivana - Mikulášková, Barbora - Behuliak, Michal - Maletínská, L. - Zicha, Josef
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Epigenetics and a new look on metabolic syndrome
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Physiological Research. 2015, Vol. 64, 5, p. 611-620
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IF = 1.618
[ASEP]
Brunová, Aneta - Bencze, Michal - Behuliak, Michal - Zicha, Josef
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Acute and chronic role of nitric oxide, renin-angiotensin system and sympathetic nervous system in the modulation of calcium sensitization in Wistar Rats
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Physiological Research. 2015, Vol. 64, 4, p. 447-457
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IF = 1.618
[ASEP]
Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
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ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood
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Physiological Research. 2015, Vol. 64, 3, p. 303-312
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IF = 1.618
[ASEP]
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Josef - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
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Stem cells regenerative properties on new rat spinal fusion model
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Physiological Research. 2015, Vol. 64, 1, p. 119-128
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IF = 1.618
[ASEP]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
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Pathogenetic Mechanisms of Neurogenic Pulmonary Edema
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Journal of Neurotrauma. 2015, Vol. 32, 15, p. 1135-1145
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IF = 4.377
[ASEP]
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doi
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Behuliak, Michal - Vavřínová, Anna - Bencze, Michal - Polgárová, Kamila - Ergang, Peter - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
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Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar–Kyoto and spontaneously hypertensive rats
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Journal of Hypertension. 2015, Vol. 33, 12, p. 2443-2454
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IF = 5.062
[ASEP]
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doi
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Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Vernerová, Z. - Zicha, Josef
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Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet
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Journal of Hypertension. 2015, Vol. 33, 1, p. 161-169
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IF = 5.062
[ASEP]
[
doi
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Maletínská, L. - Nagelová, V. - Tichá, A. - Zemenová, J. - Pirník, Z. - Holubová, M. - Špolcová, A. - Mikulášková, Barbora - Blechová, M. - Sýkora, D. - Lacinová, Z. - Haluzík, M. - Železná, B. - Kuneš, Jaroslav
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Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration
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International Journal of Obesity. 2015, Vol. 39, 6, p. 986-993
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IF = 5.337
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doi
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Bencze, Michal - Behuliak, Michal - Vavřínová, Anna - Zicha, Josef
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Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rat
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European Journal of Pharmacology. 2015, Vol. 765, Oct 15, p. 533-540
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IF = 2.73
[ASEP]
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doi
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Ergang, Peter - Vodička, Martin - Soták, Matúš - Klusoňová, Petra - Behuliak, Michal - Řeháková, Lenka - Zach, P. - Pácha, Jiří
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Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats
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Psychoneuroendocrinology. 2015, Vol. 53, Mar 2015, p. 49-59
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IF = 4.704
[ASEP]
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doi
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Kopecký, Jan - Zicha, Josef
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Recent development of biomedical research at the Institute of Physiology of the Czech Academy of Sciences in Prague
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Physiological Research. 2015, Vol. 64, 5, p. 595-609
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IF = 1.618
[ASEP]
Sobotka, O. - Drahota, Zdeněk - Kučera, O. - Endlicher, R. - Rauchová, Hana - Červinková, Z.
The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria.
Physiological Research. Vol. 64, Suppl.5 (2015), S609-S615. ISSN 0862-8408
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IF = 1.618
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal
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Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene
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Physiological Research 2014, roč. 63, 2, p. 263-265. ISSN 0862-8408.
IF = 1.293
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Vaněčková, Ivana
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Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system
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Physiological Research 2014, roč. 63, 1, p. 13-26. ISSN 0862-8408.
IF = 1.293
[ASEP]
Zicha, Josef - Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Kuneš, Jaroslav - Vaněčková, Ivana
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The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats
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Physiological Research 2014, roč. 63, suppl.1, s19-s27. ISSN 0862-8408.
IF = 1.293
[ASEP]
Vrablík, M. - Dobiášová, Milada - Zlatohlávek, L. - Urbanová, Z. - Češka, R.
Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle intervention
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Physiological Research. 2014, Vol. 63, 6, p. 745-752
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IF = 1.293
[ASEP]
Vaněčková, Ivana - Maletínská, Lenka - Behuliak, Michal - Nagelová, Veronika - Zicha, Josef - Kuneš, Jaroslav
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Obesity-related hypertension: possible pathophysiological mechanisms
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Journal of Endocrinology. 2014, roč. 223, 3, r63-r78. ISSN 0022-0795.
IF = 3.718
[ASEP]
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doi
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Sollinger, D. - Eissler, R. - Lorenz, S. - Strand, S. - Chmielewski, S. - Aoqui, C. - Schmaderer, Ch. - Bluyssen, H. - Zicha, Josef - Witzke, O. - Scherer, E. - Lutz, J. - Heemann, U. - Baumann, M.
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension
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Cardiovascular Research 2014, roč. 101, 3, p. 464-472. ISSN 0008-6363.
IF = 5.94
[ASEP]
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doi
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Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
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Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
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International Journal of Biochemistry and Cell Biology 2014, roč. 53, aug, p. 409-413. ISSN 1357-2725.
IF = 4.046
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doi
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Pintérová, Mária - Behuliak, Michal - Kuneš, Jaroslav - Zicha, Josef
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Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension
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Physiological Research 2014, roč. 63, 3, p. 275-285. ISSN 0862-8408.
IF = 1.293
[ASEP]
Líšková, Silvia - Petrová, M. - Karen, Petr - Behuliak, Michal - Zicha, Josef
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Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
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BioMed Research International 2014, roč. 2014, 2014, p. 289361. ISSN 2314-6133.
IF = 1.579
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doi
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Čertíková - Chábová, V. - Vernerová, Z. - Kujal, P. - Husková, Z. - Škaroupková, P. - Tesař, V. - Kramer, H. J. - Kompanowska - Jezierska, E. - Walkowska, A. - Sadowski, J. - Červenka, L. - Vaněčková, Ivana
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Addition of ETA receptor blockade increases renoprotection provided by renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats
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Life Sciences. 2014, roč. 118, 2, p. 297-305. ISSN 0024-3205 .
IF = 2.702
[ASEP]
[
doi
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Vaněček, Václav - Klíma, K. - Kohout, A. - Foltán, R. - Jiroušek, Ondřej - Šedý, Jiří - Štulík, J. - Syková, Eva - Jendelová, Pavla
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The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects
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European Spine Journal, 2013, Vol. 22, 12, p. 2777-2786
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IF = 2.133
[ASEP]
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doi
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Petrová, M. - Líšková, Silvia - Vojtko, R. - Villaris, R. - Varga, Z. - Zicha, Josef - Kristová, V.
Vascular reactivity of arteria femoralis in adult and aged spontaneously hypertensive and Wistar-Kyoto rats
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Bratislavske Lekarske Listy, 2013, Vol. 114, 10, p. 553-555
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IF = 0.472
[ASEP]
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doi
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Vaněčková, Ivana - Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Vorlíček, Jaroslav - Zicha, Josef
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Chronic antioxidant therapy lowers blood pressure in adult but not in young Dahl salt hypertensive rats: the role of sympathetic nervous system
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Acta Physiologica, 2013, Vol. 208, 4, p. 340-349
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IF = 4.382
[ASEP]
[
doi
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Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Behuliak, Michal - Tribulová, N. - Soukup, Tomáš
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N-3 Polyunsaturated Fatty Acids Supplementation Does not Affect Changes of Lipid Metabolism Induced in Rats by Altered Thyroid Status
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Hormone and Metabolic Research, 2013, Vol. 45, 7, p. 507-512
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IF = 2.145
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[
doi
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Langley, S. R. - Bottolo, L. - Kuneš, Jaroslav - Zicha, Josef - Zídek, Václav - Hubner, N. - Cook, S.A. - Pravenec, Michal - Aitman, T. J. - Petretto, E.
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
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Cardiovascular Research, 2013, Vol. 97, 4, p. 653-665
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IF = 5.940
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doi
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Hanzelka, T. - Dušek, J. - Ocásek, F. - Kučera, J. - Šedý, Jiří - Beneš, J. - Pavlíková, G. - Foltán, R.
Movement of the patient and the cone beam computed tomography scanner: objectives and possible solutions
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Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2013, Vol. 116, 6, p. 769-773
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IF = 1.495
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doi
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Bencze, Michal - Behuliak, Michal - Zicha, Josef
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The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats
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Physiological Research, 2013, Vol. 62, 5, p. 471-478
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IF = 1.531
[ASEP]
Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Petrová, M. - Líšková, Silvia - Karen, Petr - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
.
Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats
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Journal of Hypertension, 2013, Vol. 31, 10, p. 2025-2035
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IF = 3.806
[ASEP]
[
doi
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Šedý, Jiří - Zicha, Josef - Nedvídková, J. - Kuneš, Jaroslav
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The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats
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Journal of Applied Physiology, 2012, Vol. 112, 1, p. 1-8
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IF = 3.484
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doi
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Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav - Vaněčková, Ivana
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Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats
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Acta Physiologica, 2012, Vol. 205, 1, p. 124-132
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IF = 4.382
[ASEP]
[
doi
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Zicha, Josef - Dobešová, Zdenka - Vokurková, Martina - Rauchová, Hana - Hojná, Silvie - Kadlecová, Michaela - Behuliak, Michal - Vaněčková, Ivana - Kuneš, Jaroslav
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Age-dependent salt hypertension in Dahl rats: fifty years of research
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Physiological Research, 2012, Vol. 61, Suppl.1, S35-S87
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IF = 1.531
[ASEP]
Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Zicha, Josef
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The effects of repeated delivery of angiotensin II AT1 receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. adult animals
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Hypertension Research, 2012, Vol. 35, 7, p. 761-768
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IF = 2.791
[ASEP]
[
doi
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Vaněčková, Ivana - Kujal, P. - Husková, Z. - Vaňourková, Z. - Vernerová, Z. - Čertíková - Chábová, V. - Škaroupková, P. - Kramer, H. J. - Tesař, V. - Červenka, L.
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats
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Kidney & Blood Pressure Research, 2012, Vol. 35, 5, p. 382-392
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IF = 1.596
[ASEP]
[
doi
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Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
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Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin
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Physiological Research, 2012, Vol. 61, 3, p. 259-265
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IF = 1.531
[ASEP]
Rauchová, Hana - Vokurková, Martina - Koudelová, J.
Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis
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Physiological Research, 2012, Vol. 61, Suppl.1, S89-S101
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IF = 1.531
[ASEP]
Kuneš, Jaroslav - Kadlecová, Michaela - Vaněčková, Ivana - Zicha, Josef
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Critical developmental periods in the pathogenesis of hypertension
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Physiological Research, 2012, Vol. 61, Suppl.1, S9-S17
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IF = 1.531
[ASEP]
Hojná, Silvie - Jordan, M.D. - Kollias, H. - Pausova, Z.
High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive rats
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Hypertension Research, 2012, Vol. 35, 3, p. 279-286
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IF = 2.791
[ASEP]
[
doi
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Charvátová, Z. - Ošťádalová, Ivana - Zicha, Josef - Kuneš, Jaroslav - Maxová, H. - Ošťádal, Bohuslav
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Cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats
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Physiological Research, 2012, Vol. 61, Suppl.1, S145-S153
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IF = 1.531
[ASEP]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
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Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats
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Physiological Research, 2011, Vol. 60, 6, p. 975-979
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IF = 1.555
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Kuneš, Jaroslav - Vaněčková, Ivana
.
Preventive dietary potassium supplementation in young salt-sensitive Dahl rats attenuates development of salt hypertension by decreasing sympathetic vasoconstriction
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Acta Physiologica, 2011, Vol. 202, 1, p. 29-38
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IF = 3.090
[ASEP]
[
doi
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Vagnerová, Karla - Loukotová, Jana - Ergang, Peter - Musílková, Jana - Mikšík, Ivan - Pácha, Jiří
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Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells
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Steroids, 2011, Vol. 76, 6, p. 577-581
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IF = 2.829
[ASEP]
[
doi
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Rašlová, K. - Dobiášová, Milada - Hubáček, J. A. - Bencová, D. - Siváková, D. - Danková, Z. - Franeková, J. - Jabor, A. - Gašparovič, J. - Vohnout, B.
Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population
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Physiological Research, 2011, Vol. 60, 5, p. 758-795
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IF = 1.555
[ASEP]
Rauchová, Hana - Mráček, Tomáš - Novák, Petr - Vokurková, Martina - Soukup, Tomáš
.
Glycerol-3-phosphate Dehydrogenase Expression and Oxygen Consumption in Liver Mitochondria of Female and Male Rats with Chronic Alteration of Thyroid Status
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Hormone and Metabolic Research, 2011, Vol. 43, 1, p. 43-47
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IF = 2.188
[ASEP]
[
doi
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Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
.
Altered neural and vascular mechanisms in hypertension
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Physiological Research, 2011, Vol. 60, 3, p. 381-402
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IF = 1.555
[ASEP]
Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
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Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery
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European Journal of Pharmacology, 2011, Vol. 667, 1-3, p. 265-270
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IF = 2.516
[ASEP]
[
doi
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Klusoňová, Petra - Pátková, Lenka - Ergang, Peter - Mikšík, Ivan - Zicha, Josef - Kuneš, Jaroslav - Pácha, Jiří
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Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats – Effect of hypertriglyceridemia and gender
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Steroids, 2011, Vol. 76, 12, p. 1252-1259
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IF = 2.829
[ASEP]
[
doi
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Dobiášová, Milada - Frohlich, J. - Šedová, Michaela - Cheung, M. C. - Brown, B.G.
Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography
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Journal of Lipid Research, 2011, Vol. 52, 3, p. 566-571
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IF = 5.559
[ASEP]
[
doi
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Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
.
Vasodilator efficiency of endogenous prostanoids, Ca2+-activated K+ channels and nitric oxide in rats with spontaneous, salt-dependent or NO-deficient hypertension
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Hypertension Research, 2011, Vol. 34, 8, p. 968-975
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IF = 2.576
[ASEP]
[
doi
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Zicha, Josef - Vaněčková, Ivana - Kuneš, Jaroslav
.
Systems Analysis in Hypertension: Complementary Role of Physiologists and Geneticists
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Physiological Research, 2010, Vol. 59, 6, p. 837-839
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IF = 1.646
[ASEP]
Pintérová, Mária - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
.
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
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Journal of Hypertension, 2010, Vol. 28, 5, p. 969-978
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IF = 3.980
[ASEP]
[
doi
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Paulis, L. - Pecháňová, Olga - Zicha, Josef - Barta, A. - Gardlik, R. - Celec, P. - Kuneš, Jaroslav - Šimko, F.
Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension
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Journal of Pineal Research, 2010, Vol. 48, 2, p. 102-108
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IF = 5.855
[ASEP]
[
doi
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Paulis, L. - Pecháňová, Olga - Zicha, Josef - Líšková, Silvia - Celec, P. - Müllerová, M. - Kollár, J. - Behuliak, M. - Kuneš, Jaroslav - Adamcová, M. - Šimko, F.
Melatonin improves the restoration of endothelium-derived constricting factor signalling and inner diameter in the rat femoral artery after cessation of L-NAME treatment
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Journal of Hypertension, 2010, Vol. 28, Suppl.1, S19-S24
.
IF = 3.980
[ASEP]
[
doi
]
Hojná, Silvie - Kuneš, Jaroslav - Zicha, Josef
.
Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension
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Physiological Research, 2010, Vol. 59, 6, p. 997-1009
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IF = 1.646
[ASEP]
Šimko, F. - Pecháňová, Olga
.
Recent trends in hypertension treatment: perspectives from animal studies
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Journal of Hypertension, 2009, Vol. 27, Suppl.6, S1-S4
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IF = 4.988
[ASEP]
[
doi
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Šimko, F. - Pecháňová, Olga
.
Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment
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Journal of Pineal Research, 2009, Vol. 47, 2, p. 127-133
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IF = 5.209
[ASEP]
[
doi
]
Šimko, F. - Pecháňová, Olga - Pelouch, Václav - Krajčírovičová, K. - Müllerová, M. - Bednárová, K. - Adamcová, M. - Paulis, L.
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
.
Journal of Hypertension, 2009, Vol. 27, Suppl.6, S5-S10
.
IF = 4.988
[ASEP]
[
doi
]
Šedý, Jiří - Zicha, Josef - Kuneš, Jaroslav - Hejčl, Aleš - Syková, Eva
.
The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions
.
American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2009, Vol. 297, 4, R1111-R1117
.
IF = 3.058
[ASEP]
[
doi
]
Šedý, Jiří - Zicha, Josef - Kuneš, Jaroslav - Jendelová, Pavla - Syková, Eva
.
Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat
.
Physiological Research, 2009, Vol. 58, 2, p. 269-277
.
IF = 1.430
[ASEP]
Šedý, Jiří - Zicha, Josef - Kuneš, Jaroslav - Syková, Eva
.
Atropine may prevent the development of neurogenic pulmonary edema
.
Medical Hypotheses, 2009, Vol. 73, 1, p. 42-44
.
IF = 1.393
[ASEP]
[
doi
]
Zicha, Josef - Kuneš, Jaroslav - Vranková, S. - Jendeková, L. - Dobešová, Zdenka - Pintérová, Mária - Pecháňová, Olga
.
Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension
.
Physiological Research, 2009, Vol. 58, 5, p. 751-755
.
IF = 1.430
[ASEP]
Vranková, S. - Jendeková, L. - Paulis, L. - Sládková, M. - Šimko, F. - Pecháňová, Olga
.
Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension
.
Journal of Hypertension, 2009, Vol. 27, Suppl.6, S42-S46
.
IF = 4.988
[ASEP]
[
doi
]
Rauchová, Hana - Vokurková, Martina
.
Současný pohled na koenzym Q
.
Chemické listy, 2009, Vol. 103, 1, p. 32-39
.
IF = 0.717
[ASEP]
Pecháňová, Olga - Jendeková, L. - Vranková, S.
Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension
.
Pharmacological Reports, 2009, Vol. 61, 1, p. 116-122
.
IF = 2.086
[ASEP]
Pecháňová, Olga - Kuneš, Jaroslav - Dobešová, Zdenka - Vranková, S. - Zicha, Josef
.
Contribution of neuronal NO synthase to N-acetylcysteine-induced increase of NO synthase activity in the brain of normotensive and hypertensive rats
.
Journal of Physiology and Pharmacology, 2009, Vol. 60, 4, p. 21-25
.
IF = 1.489
[ASEP]
Pecháňová, Olga - Šimko, F.
Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind
.
Journal of Hypertension, 2009, Vol. 27, Suppl.6, S32-S36
.
IF = 4.988
[ASEP]
[
doi
]
Paulis, L. - Pecháňová, Olga - Zicha, Josef - Krajčírovičová, K. - Barta, A. - Pelouch, V. - Adamcová, M. - Šimko, F.
Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats
.
Journal of Hypertension, 2009, Vol. 27, Suppl.6, S11-S16
.
IF = 4.988
[ASEP]
[
doi
]
Matejíková, J. - Kucharská, J. - Pintérová, Mária - Pancza, D. - Ravingerová, T.
Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: involvement of mitochondrial KATP channels and reactive oxygen species
.
Physiological Research, 2009, Vol. 58, 1, p. 9-19
.
IF = 1.430
[ASEP]
Kuneš, Jaroslav - Zicha, Josef
.
The interaction of genetic and environmental factors in the etiology of hypertension
.
Physiological Research, 2009, Vol. 58, Suppl.2, S33-S41
.
IF = 1.430
[ASEP]
Hubáček, J. A. - Adámková, V. - Vrablík, M. - Kadlecová, Michaela - Zicha, Josef - Kuneš, Jaroslav - Piťha, J. - Suchánek, P. - Poledne, R.
Apolipoprotein A5 in health and disease
.
Physiological Research, 2009, Vol. 58, Suppl.2, S101-S109
.
IF = 1.430
[ASEP]
Endlicher, R. - Křiváková, P. - Rauchová, Hana - Nůsková, Hana - Červinková, Z. - Drahota, Zdeněk
.
Peroxidative damage of mitochondrial respiration is substrate-dependent
.
Physiological Research, 2009, Vol. 58, 5, p. 685-692
.
IF = 1.430
[ASEP]
Bal, Manjot Singh - Paulis, Ĺudovít - Zicha, Josef - Kuneš, Jaroslav
.
Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats
.
Physiological Research, 2009, Vol. 58, 6, p. 793-798
.
IF = 1.430
[ASEP]
Pintérová, Mária - Líšková, Silvia - Dobešová, Zdenka - Behuliak, M. - Kuneš, Jaroslav - Zicha, Josef
.
Impaired control of L-type voltage-dependent calcium channels in experimental hypertension
.
Physiological Research, 2009, Vol. 58, Suppl.2, S43-S54
.
IF = 1.430
[ASEP]
Šedý, Jiří - Zicha, Josef - Kuneš, Jaroslav - Jendelová, Pavla - Syková, Eva
.
Mechanisms of neurogenic pulmonary edema development
.
Physiological Research, 2008, Vol. 57, 4, p. 499-506
.
IF = 1.653
[ASEP]
Šedý, Jiří - Likavčanová, Katarína - Urdzíková, Lucia - Zicha, Josef - Kuneš, Jaroslav - Hejčl, A. - Jendelová, Pavla - Syková, Eva
.
Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
.
Medical Hypotheses, 2008, Vol. 70, 2, p. 308-313
.
IF = 1.416
[ASEP]
Červinková, Z. - Rauchová, Hana - Křiváková, P. - Drahota, Zdeněk
.
Inhibition of Palmityl Carnitine Oxidation in Rat Liver Mitochondria by Tert-Butyl Hydroperoxide
.
Physiological Research, 2008, Vol. 57, 1, p. 133-136
.
IF = 1.653
[ASEP]
Čačányiová, S. - Kristek, F. - Kuneš, Jaroslav - Zicha, Josef
.
The effects of pertussis toxin-treatment on integrated vasoactive response of vascular system in spontaneously hypertensive rats
.
Physiological Research, 2008, Vol. 57, 1, p. 137-139
.
IF = 1.653
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav
.
Late blood pressure reduction in shr subjected to transient captopril treatment in youth: possible mechanisms
.
Physiological Research, 2008, Vol. 57, 3, p. 495-498
.
IF = 1.653
[ASEP]
Zemančíková, A. - Török, J. - Zicha, Josef - Kuneš, Jaroslav
.
Inactivation of Gi proteins by pertussis toxin diminishes the effectiveness of adrenergic stimuli in conduit arteries from spontaneously hypertensive rats
.
Physiological Research, 2008, Vol. 57, 2, p. 299-302
.
IF = 1.653
[ASEP]
Vrablík, M. - Dobiášová, Milada - Štulc, T. - Kasalová, Z. - Doležalová, R. - Prázný, M. - Fait, T. - Češka, R.
Fenofibrate and rosiglitazone improve quality of lipoproteins in patients with type 2 diabetes mellitus
.
Neuroendocrinology Letters, 2008, Vol. 29, 1, p. 146-150
.
IF = 1.359
[ASEP]
Rauchová, Hana - Drahota, Zdeněk - Bergamini, C. - Fato, R. - Lenaz, G.
Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone)
.
Journal of Bioenergetics and Biomembranes, 2008, Vol. 40, 2, p. 85-93
.
IF = 2.480
[ASEP]
[
doi
]
Paulis, Ĺudovít - Zicha, Josef - Kuneš, Jaroslav - Hojná, Silvie - Behuliak, M. - Celec, P. - Kojšová, S. - Pecháňová, O. - Šimko, F.
Regression of L-NAME−Induced Hypertension: The Role of Nitric Oxide and Endothelium-Derived Constricting Factor
.
Hypertension Research, 2008, Vol. 31, 4, p. 793-803
.
IF = 3.146
[ASEP]
Mikulíková, Kateřina - Eckhardt, Adam - Kuneš, Jaroslav - Zicha, Josef - Mikšík, Ivan
.
Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake
.
Physiological Research, 2008, Vol. 57, 1, p. 89-94
.
IF = 1.653
[ASEP]
Lamounier-Zepter, V. - Bornstein, S.R. - Kuneš, Jaroslav - Zicha, Josef - Kršek, M. - Ehrhart-Bornstein, M. - Ziegler, Ch.G. - Kiessling, A. - Funk, R.H. - Haluzík, M.
Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice
.
Molecular and Cellular Endocrinology, 2008, Vol. 280, 1-2, p. 39-46
.
IF = 3.611
[ASEP]
Kuneš, Jaroslav - Dobešová, Zdenka - Musilová, Alena - Zídek, Václav - Vorlíček, Jaroslav - Pravenec, Michal - Křen, Vladimír - Zicha, Josef
.
Hemodynamic Characterization of Recombinant Inbred Strains: Twenty Years Later
.
Hypertension Research, 2008, Vol. 31, 8, p. 1659-1668
.
IF = 3.146
[ASEP]
Kristová, V. - Líšková, Silvia - Sotníková, R. - Vojtko, R. - Kurtanský, A.
Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats
.
Physiological Research, 2008, Vol. 57, 3, p. 491-494
.
IF = 1.653
[ASEP]
Kadlecová, Michaela - Dobešová, Zdenka - Zicha, Josef - Kuneš, Jaroslav
.
Abnormal Igf 2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids
.
Molecular and Cellular Biochemistry, 2008, Vol. 314, 1-2, p. 37-43
.
IF = 1.764
[ASEP]
[
doi
]
Šimko, F. - Potáčová, A. - Pelouch, V. - Paulis, L. - Matúšková, J. - Krajčírovičová, K. - Pecháňová, Olga - Adamcová, M.
Spontaneous, L-Arginine-Induced and Spironolactone-Induced Regression of Protein Remodeling of the Left Ventricle in L-NAME-Induced Hypertension
.
Physiological Research, 2007, Vol. 56, Suppl.2, S55-S62
.
IF = 1.505
[ASEP]
Šimko, F. - Matúšková, J. - Ľupták, I. - Pinčíková, T. - Krajčírovičová, K. - Štvrtina, S. - Pomšár, J. - Pelouch, V. - Paulis, L. - Pecháňová, Olga
.
Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension
.
Physiological Research, 2007, Vol. 56, Suppl.2, S25-S32
.
IF = 1.505
[ASEP]
Zobrazit více
Přehled změn vápníkové sensitizace za vývoje spontánní hypertenze potkana Schéma možných regulačních mechanismů účastnících se RhoA/Rho kinázové dráhy, které byly zjištěny u normotenzních (a), prehypertenzních (b) a hypertenzních (c) potkanů.
Průběh záznamu kontrakce izolované femorální artérie vyvolané noradrenalinem (NE, norepinefrin).
