Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.
We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:
- Study of influence epigenetic factors on heart development.
- Analysis of mechanisms of embryonic heart failure.
- Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
- Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.
These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.
Projects
Achievements
Publications
Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V.
Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload
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Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367
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IF = 4.031
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doi
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Pérez-Pomares, J. M. - de la Pompa, J. L. - Franco, D. - Henderson, D. - Ho, S. Y. - Houyel, L. - Kelly, R. G. - Sedmera, David - Sheppard, M. - Sperling, S. - Thiene, G. - van den Hoff, M. - Basso, C.
Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group
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Cardiovascular Research. 2016, roč. 109, 2, p. 204-216
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IF = 5.465
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doi
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Krejčí, Eliška - Peševski, Živorad - Naňka, O. - Sedmera, David
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Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system
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Physiological Research. 2016, roč. 65, 3, p. 425-435
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IF = 1.618
[ASEP]
Kolesová, H. - Čapek, Martin - Radochová, Barbora - Janáček, Jiří - Sedmera, David
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Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts
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Histochemistry and Cell Biology. 2016, roč. 146, 2, p. 142-152
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IF = 2.780
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doi
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Kočková, Radka - Kačer, P. - Pirk, J. - Malý, J. - Sukupová, L. - Sikula, V. - Kotrc, M. - Barciaková, L. - Honsová, E. - Malý, M. - Kautzner, J. - Sedmera, David - Penicka, M.
Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -
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Circulation Journal. 2016, roč. 80, 5, p. 1202-1209
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IF = 4.124
[ASEP]
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doi
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Živorad Peševski (2012)
František Vostárek (2013)
