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Cardiovascular Morphogenesis

Cardiovascular Morphogenesis Epicardial activation maps showing spreading of action potential by measuring calcium transients in a three days old embryonic chick heart.

We study cardiovascular development with a special emphasis on the cardiac conduction system. Our research is at present focused mainly on:

  • Study of influence epigenetic factors on heart development.
  • Analysis of mechanisms of embryonic heart failure.
  • Development and implementation of novel imaging techniques to study embryonic myocardial architecture as a substrate for preferential conduction pathways in the developing heart.
  • Analysis of mouse mutants with embryonic arrhythmias and perturbations of myocardial architecture.

These topics are currently supported by GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis" and 13-12412S “Development of mouse conduction system analyzed by 3D imaging and optical mapping”.

Projects

Achievements

Publications

Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload . Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367 . IF = 4.031 [ASEP] [ doi ]
Pérez-Pomares, J. M. - de la Pompa, J. L. - Franco, D. - Henderson, D. - Ho, S. Y. - Houyel, L. - Kelly, R. G. - Sedmera, David - Sheppard, M. - Sperling, S. - Thiene, G. - van den Hoff, M. - Basso, C. Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group . Cardiovascular Research. 2016, roč. 109, 2, p. 204-216 . IF = 5.465 [ASEP] [ doi ]
Krejčí, Eliška - Peševski, Živorad - Naňka, O. - Sedmera, David . Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system . Physiological Research. 2016, roč. 65, 3, p. 425-435 . IF = 1.618 [ASEP]
Kolesová, H. - Čapek, Martin - Radochová, Barbora - Janáček, Jiří - Sedmera, David . Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts . Histochemistry and Cell Biology. 2016, roč. 146, 2, p. 142-152 . IF = 2.780 [ASEP] [ doi ]
Kočková, Radka - Kačer, P. - Pirk, J. - Malý, J. - Sukupová, L. - Sikula, V. - Kotrc, M. - Barciaková, L. - Honsová, E. - Malý, M. - Kautzner, J. - Sedmera, David - Penicka, M. Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy - . Circulation Journal. 2016, roč. 80, 5, p. 1202-1209 . IF = 4.124 [ASEP] [ doi ]

Article photogallery

The entire photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Cardiovascular Morphogenesis

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 561
fax. +420 241 062 125
   

david.sedmera@fgu.cas.cz

People

Prof. MUDr. David Sedmera, D.Sc.
senior scientist
  Mgr. Barbora Šaňková
PhD student
MUDr. Radka Kočková
PhD student
MUDr. Živorad Peševski
PhD student
Mgr. František Vostárek
PhD student
Ing. Eliška Krejčí, Ph.D.
technician
Jarmila Svatůňková
technician

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