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Organic chemistry

Tutor Mgr. Filip Teplý, Ph.D.
Team Filip Teplý
Topic Resolution of Helquats on a Large Scale
Faculty FCHT VŠCHT, PřF UK
Abstract

Helquats represent a very recent addition into the word of small helical aromatics. To address the issues depending on their helical chirality, a robust preparative access to non-racemic series is essential. The goal of this project is to secure a general, cheap, and user-friendly access to multigram quantities of non-racemic helquats. Also applications of non-racemic helquats will be an important part of this project.

Leading references:

Adriaenssens L., Severa L., Šálová T., Císařová I., Pohl R., Šaman D., Rocha S. V., Finney N. S., Pospíšil L., Slavíček P., Teplý F.:
Helquats: A Facile, Modular, Scalable Route to Novel Helical Dications
Chemistry - A European Journal 2009, 15, 1072.

Jacques J., Collet A., Wilen S. H., Enantiomers, Racemates, and Resolutions, 2nd ed., Krieger, Malabar, Florida, 1994.